Bacitracin | 杆菌肽 _ MedChemExpress (MCE)

参考详情：Bacitracin (杆菌肽) - 仅供科研 | 多肽抗生素 | MCE

中文名：杆菌肽

CAS：1405-87-4

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：杆菌肽是一种多肽抗生素，用于葡萄球菌感染。杆菌肽通过与焦磷酸十一碳烯基酯结合，起到细胞壁生物合成抑制剂的作用。杆菌肽与其他抗生素的组合已被有效地用作外用剂[1]。

体外：Bacitracin (64 μg/mL，24 h) 与粘菌素一起显示出对 S. aureus BA01611 的抗菌活性[1]. Bacitracin (64 μg/mL，1或2 h) 破坏细胞表面，使其形成葡萄状细胞团，使得细胞边界模糊不清[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Bacitracin (0-100 mg/kg，肌肉注射，每日一次，连续 12 天) 在 HCC 模型中显示出抗肿瘤功效[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: HCC model (MH134 cells implanted)[3] Dosage: 0, 10, 50, and 100 mg/kg Administration: Intramuscular injection (i.m), daily for 12 consecutive days. Result: Decreased tumor volumes. Decreased the percentage of PDI-stained vascular densities. Clinical Trial

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研究领域：Anti-infection  |  Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage

作用靶点：Bacterial  |  Antibiotic  |  PDI

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

参考文献：

[1]. Si W, et al. Colistin Induces S. aureus Susceptibility to Bacitracin. Front Microbiol. 2018 Nov 20;9:2805.

[2]. Mohamed Faisal, et al. Bacitracin Inhibits the Oyster Pathogen Perkinsus marinus in Vitro and in Vivo. Journal of Aquatic Animal Health. Volume 11, 1999 - Issue 2.

[3]. Yu SJ, et al. Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition. J Bioenerg Biomembr. 2012 Feb;44(1):101-15.

 

 

 

 

 

 

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