参考详情:Golimumab (CNTO-148,戈利木单抗) - 仅供科研 | TNFα拮抗剂 | MCE
CAS:476181-74-5
品牌:MedChemExpress (MCE)
存储条件:Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性:Golimumab (CNTO-148) 是一种有效的人 IgG1 TNFα 拮抗剂单克隆抗体。 Golimumab 具有抗炎活性并抑制 IL-6 和 IL-1β 的产生。 Golimumab 通过靶向和中和 TNF 来预防炎症和软骨和骨骼的破坏。 Golimumab 具有抗癌活性并诱导细胞凋亡。戈利木单抗可用于类风湿性关节炎、克罗恩病和癌症研究[1][2][3]。
体外:Golimumab (CNTO-148)(0.1-10 μg /mL;24-72 小时;跨膜 TNFα 转染的 Jurkat 细胞)诱导跨膜 TNFα 表达细胞的活力降低[1]。
Golimumab (CNTO-148)(10 μg /mL;48 小时;跨膜 TNFα 转染 Jurkat 细胞)诱导细胞凋亡,增加活性 caspase-3 的水平并诱导细胞凋亡 DNA 片段化[1] .
体内:Golimumab (CNTO-148)(24 mg/kg;ih;每天一次,持续 7 天;瑞士白化健康雄性小鼠)抑制氧化应激、凋亡细胞死亡炎症反应,从而改善肾功能。 Golimumab 可减少所有肾损伤标志物并减轻细胞死亡[2]。
Golimumab (CNTO-148)(1-10 mg/kg;ip;每天;持续 4 周;Tg197 转基因mouse model) 在人类小鼠模型中减轻 TNFα 诱导的关节炎[3]。
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研究领域:Apoptosis | Immunology/Inflammation
作用靶点:TNF Receptor | Apoptosis | Interleukin Related | Caspase
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:
[1]. Ueda N, et, al. The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α. Inflamm Bowel Dis. 2013 May;19(6):1224-31.
[2]. Pavitrakar V, et, al. Amelioration of Cisplatin-induced Renal Inflammation by Recombinant Human Golimumab in Mice. Curr Pharm Biotechnol. 2022;23(7):970-977.
[3]. Shealy DJ, et, al. Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α. MAbs. 2010 Jul-Aug;2(4):428-39.