中文名:雷诺嗪
CAS:95635-55-5
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Ranolazine (CVT 303) 是一种抗心绞痛药物,通过抑制晚期内向钠电流(INa 和 IKr,IC50 值分别为 6 μM 和 12 μM),不影响心率或血压(英国石油公司)[1][2]。 Ranolazine 也是一种部分脂肪酸氧化 (FAO) 抑制剂[3]。抗心绞痛药。 IC50 和目标:IC50:6 μM (INa),12 μM (IKr)[1]
体内:雷诺嗪(推注 10 mg/kg 和输注 9.6 mg/kg/h;推注;持续 145 分钟;雄性 Wistar 大鼠)治疗显着减少左前降支冠状动脉闭塞再灌注大鼠的梗塞面积和心肌肌钙蛋白 T 释放[3]。
参考详情:https://www.medchemexpress.com/ranolazine.html
参考文献:
[1]. Keating GM. Ranolazine: a review of its use as add-on therapy in patients with chronic stable angina pectoris. Drugs. 2013 Jan;73(1):55-73.
[2]. Wang WQ, et al. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81.
[3]. Zacharowski K, et al. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.