J South Med Univ, 2019, 39(2): 227-234 doi 10.12122/j.issn. 1673-4254.2019.02.16 ·227 ·
肾病肾病ⅢⅢ号方治疗慢性号方治疗慢性肾脏病蛋白尿的机制肾脏病蛋白尿的机制::基于网络药理学方法基于网络药理学方法
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刘华熙 ,吕智豪 ,田春阳 ,欧阳文坤 ,熊一凡 ,游艳婷 ,陈立倩 ,邓伊健 ,赵晓山 ,孙晓敏
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南方医科大学中医药学院,广东 广州 510515 ;广州中医药大学第一临床医学院,广东 广州 510405
摘要:目的基于网络药理学探讨肾病Ⅲ号方的主要活性成分、靶点及治疗慢性肾脏病蛋白尿的作用机制。方法 结合口服生物
利用度和类药性,在TCMSP 数据库中寻找与肾病Ⅲ号方组方中药相关的活性成分、靶点,在GeneCards 数据库搜索蛋白尿相关
靶点,采用Cytoscape 软件构建活性成分-靶点网络,并将获取的靶点信息利用ClueGO 进行基因通路的富集分析。结果 从肾病
Ⅲ号方中筛选获得102个活性成分、作用于126个靶点,与蛋白尿相关的靶点69个,流体剪切应力和动脉粥样硬化相关通路显
著性高。结论 初步验证了肾病Ⅲ号方的组方合理性及其治疗慢性肾脏病蛋白尿的科学性,并为进一步深入探讨肾病Ⅲ号方治
疗慢性肾脏病蛋白尿的机制奠定理论基础。
关键词:网络药理学;肾病Ⅲ号方;慢性肾脏病;蛋白尿;作用机制
Mechanism of Shenbing decoction III in the treatment of proteinuria in chronic kidney
disease: a network pharmacology-based study
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LIU Huaxi , LÜ Zhihao , TIAN Chunyang , OUYANG Wenkun , XIONG Yifan , YOU Yanting , CHEN Liqian , DENG Yijian , ZHAO
Xiaoshan1, SUN Xiaomin1
1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; 2First Clinical Medical College,
Guangzhou University of Chinese Medicine, Guangzhou 510405, China
Abstract: Objective To identify the main active components in Shenbing decoction III and their targets and explore the
mechanism by which Shenbing decoction III alleviates proteinuria in chronic kidney disease (CKD) based on network
pharmacology. Methods The active components of Shenbing decoction III and their potential targets, along with the oral
bioavailability and drug-like properties of each component were searched in the TCMSP database. The proteinuria-related
targets were searched in the GeneCards dat