NeurIPS2020有关可解释性的文章

Fourier-transform-based attribution priors improve the interpretability and stability of deep learning models for genomics

• https://proceedings.neurips.cc/paper/2020/hash/1487987e862c44b91a0296cf3866387e-Abstract.html
  -摘要：Deep learning models can accurately map genomic DNA sequences to associated functional molecular readouts such as protein-DNA binding data. Base-resolution importance (i.e. “attribution”) scores inferred from these models can highlight predictive sequence motifs and syntax. Unfortunately, these models are prone to overfitting and are sensitive to random initializations, often resulting in noisy and irreproducible attributions that obfuscate underlying motifs. To address these shortcomings, we propose a novel attribution prior, where the Fourier transform of input-level attribution scores are computed at training-time, and high-frequency components of the Fourier spectrum are penalized. We evaluate different model architectures with and without our attribution prior, training on genome-wide binary labels or continuous molecular profiles. We show that our attr