孟德尔随机化：去除连锁不平衡时clump_data函数报错解决

问题

在孟德尔随机化分析中，使用TwoSampleMR包中的clump_data函数跑连锁不平衡时，遇到如下报错：

exposure_dat_clumped <- clump_data(exposure_dat, clump_kb=10000, clump_r2=0.001)

Please look at vignettes for options on running this locally if you need to run many instances of this command. Clumping Z6Yd1i, 2041 variants, using EUR population reference No encoding supplied: defaulting to UTF-8. Error in mtfrm.default(list(url = "https://api.opengwas.io/api/ld/clump",  :   cannot mtfrm

解决方案

调用API接口：

options(ieugwasr_api = 'gwas-api.mrcieu.ac.uk/')

运行成功🎉🎉🎉