Paper reading (九十三)：Efficacy of a multispecies probiotic in generalized anxiety disorder

论文题目：Efficacy of a multispecies probiotic as adjunctive therapy in generalized anxiety disorder: a double blind, randomized, placebo-controlled trial

scholar 引用：1

页数：7

发表时间：13 Sep 2019

发表刊物：Nutritional neuroscience

作者：Eskandarzadeh, ..., Mahnaz Jazayeri, Shima

作者单位：Iran University of Medical Sciences

摘要：

Objectives: Studies have shown that probiotics may decrease anxiety symptoms, but to our knowledge so far no trial has investigated the effects of probiotics in generalized anxiety disorder (GAD, 广泛性焦虑障碍). The aim of the present study was to determine the effects of probiotics as adjunctive therapy on anxiety severity and quality of life (QOL, 生活质量) in patients with GAD.

Methods: Forty-eight drug-free patients with a diagnosis of GAD based on DSM-V(精神疾病诊断与统计手册第五版) criteria were randomly assigned to two groups to receive daily either one capsule of probiotics or placebo in addition to 25 mg sertraline(舍曲林) for 8 weeks. Probiotic capsules contained 18*109 CFU(菌落总数) Bifidobacterium longom(长双歧杆菌), Bifidobacterium bifidum(两岐双岐杆菌), Bifidobacterium lactis(乳酸双歧杆菌) and Lactobacillus acidophilus bacteria(嗜酸乳杆菌细菌).

Results: Intention to treat analysis was performed in 39 Patients who completed at least 4 weeks of the intervention. After 8 weeks, the score of Hamilton Rating Scale for anxiety (HAM-A, 汉密尔顿焦虑量表) decreased more in the probiotics + sertraline (PS) group (p = 0.003). Although the reduction of Beck Anxiety Inventory (BAI, 贝克焦虑量表) was also more in the PS group, it was not significantly different from that of the sertraline alone(S) group. Moreover, despite the greater reduction of State-Anxiety Inventory score in the PS group, the score of Trait-Anxiety Inventory(特质焦虑量表) was not statistically different between the two groups at week 8. With regard to QOL, there was no significant difference between the two groups in the change of the score of QOL domains.

Conclusions: Probiotics + sertraline combination was superior to sertraline alone in decreasing anxiety symptoms after 8 weeks in patients with GAD, although it did not affect QOL.

KEYWORDS Generalized anxiety disorder; probiotic; sertraline; quality of life; anxiety

临床心理学中，有哪些常用焦虑诊断量表？

正文组织架构：

1. Introduction

2. Material and method

2.1 Trial design

2.2 Participants

2.3 Intervention

2.4 Outcomes

2.5 Statistical methods

3. Results

4. Discussion

正文部分内容摘录：

1. 健康还是特定疾病？多少个体和组别？就是说这些组别的个体是对健康个体进行干预，还是特定疾病的人在干预？

• Forty-eight drug-free patients with a diagnosis of GAD based on DSM-V(精神疾病诊断与统计手册第五版) criteria were randomly assigned to two groups to receive daily either one capsule of probiotics or placebo in addition to 25 mg sertraline(舍曲林) for 8 weeks.
• Intention to treat analysis was performed in 39 Patients who completed at least 4 weeks of the intervention.

2. 有哪些组学数据可利用？组学数据的下载ID是什么？

• The protocol, prepared in accordance with the latest version of the Helsinki declaration, was registered in Iranian Registry of Clinical Trials (Ref#: IRCT201612072394N35). The study was approved by Ethics committee, Iran University of Medical Sciences (IR.IUMS.REC 1395.9411468002).

• Sharing plan: empty

3. 研究的干预基本结果和结论是什么？

• Results: Intention to treat analysis was performed in 39 Patients who completed at least 4 weeks of the intervention. After 8 weeks, the score of Hamilton Rating Scale for anxiety (HAM-A, 汉密尔顿焦虑量表) decreased more in the probiotics + sertraline (PS) group (p = 0.003). Although the reduction of Beck Anxiety Inventory (BAI, 贝克焦虑量表) was also more in the PS group, it was not significantly different from that of the sertraline alone(S) group. Moreover, despite the greater reduction of State-Anxiety Inventory score in the PS group, the score of Trait-Anxiety Inventory(特质焦虑量表) was not statistically different between the two groups at week 8. With regard to QOL, there was no significant difference between the two groups in the change of the score of QOL domains.

• Conclusions: Probiotics + sertraline combination was superior to sertraline alone in decreasing anxiety symptoms after 8 weeks in patients with GAD, although it did not affect QOL.

• Our study had some limitations. Compliance of participants and intestinal probiotic colonization were not determined by stool exam. It is suggested that future clinical trials should investigate the intestinal probiotic colonization.