D-Galactosamine hydrochloride D-半乳糖胺盐酸盐（CAS号： 1772-03-8）

D-Galactosamine hydrochloride（D-半乳糖胺盐酸盐）是一种实验毒素，可用于构建动物肝损伤模型。

1.生物活性

D-Galactosamine hydrochloride又叫D-半乳糖胺盐酸盐，是一种肝细胞核苷代谢干扰剂，能持续性地损伤肝细胞，主要用于肝脏病理、生化的研究，用它复制的肝炎模型，接近人体肝炎的病理改变，对于筛选和研究抗肝炎药物是较为可靠和有用的。D-半乳糖盐酸盐通过防止COX-2 N-糖基化和以蛋白酶体依赖的方式增加COX-2蛋白的转换，特异性地抑制COX-2。

2.化学性质

分子量：215.63

分子式：C6H13NO5.HCl

CAS号：1772-03-8

溶解性：Water 4 mg/mL

储存条件：2-8°C, dry, protect from light, sealed

运输方式：冰袋运输，根据产品的不同，可能会有相应调整。

3.储备液配置

4.参考文献

[1] Sevim Tunali, et al. The effects of vitamins and selenium mixture against brain tissue induced by d-galactosamine

[2] Wei Wang, et al. Synergistic effects of antibodies against high-mobility group box 1 and tumor necrosis factor-α antibodies on D-(+)-galactosamine hydrochloride/lipopolysaccharide-induced acute liver failure

[3] Kei Miyanaga, et al. Influence of murine hepatitis induced by D-(+)-galactosamine hydrochloride and lipopolysaccharide on gene expression of polyethylenimine/plasmid DNA polyplex

[4] Toshihiro Otsuka, et al. Prevention of lethal hepatic injury in Long-Evans Cinnamon (LEC) rats by D-galactosamine hydrochloride

[5] C H Bauer, et al. Studies on the golgi apparatus. Cumulative inhibition of protein and glycoprotein secretion by D-galactosamine