Scrambled-Beta-Amyloid (1-40) | 1678415-68-3 | AEGDSHVLKEGAYMEIFDVQGHVFGGKIFRVVDLGSHNVA

Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder characterized by aberrant amyloid precursor protein (APP) cleavage, pathological aggregations of beta-amyloid (Aβ) that make up Aβ plaques and hyperphosphorylation of Tau that makes up neurofibrillary tangles (NFTs).

Amyloid pathology, which is one of the characteristics of Alzheimer’s disease (AD), results from altered metabolism of the beta-amyloid (Aβ) peptide in terms of synthesis, clearance, or aggregation. A decrease in cerebrospinal fluid (CSF) level Aβ1–42 is evident in AD, and the CSF ratio Aβ42/Aβ40 has recently been identified as one of the most reliable diagnostic biomarkers of amyloid pathology. 

淀粉样蛋白病理是阿尔茨海默病（AD）的特征之一，是由β-淀粉样蛋白（Aβ）肽在合成、清除或聚集方面的代谢改变引起的。AD患者脑脊液（CSF）水平Aβ1–42明显下降，CSF比率Aβ42/Aβ40最近被确定为淀粉样蛋白病理最可靠的诊断生物标志物之一。

Beta-Amyloid 1-40, scrambled 是 Beta-Amyloid 1-40 的乱序序列，与 Beta-Amyloid 1-40 活性片段具有相同的氨基酸组成，常用作阴性对照。

中文或英文名称：
Scramble-beta-Amyloid 1-40 | Beta-Amyloid 1-40, scrambled | Scrambled-β-Amyloid 1-40 | Scrambled-Aβ1-40 | Scrambled-Abeta42 | Scrambled-Abeta 1-40 | Scrambled-β-淀粉样多肽 1-40

序列(单字母)：AEGDSHVLKEGAYMEIFDVQGHVFGGKIFRVVDLGSHNVA
序列(三字母):    H-Ala-Glu-Gly-Asp-Ser-His-Val-Leu-Lys-Glu-Gly-Ala-Tyr-Met-Glu-Ile-Phe-Asp-Val-Gln-Gly-His-Val-Phe-Gly-Gly-Lys-Ile-Phe-Arg-Val-Val-Asp-Leu-Gly-Ser-His-Asn-Val-Ala-OH
CAS: 1678415-68-3
分子式： C194H295N53O58S1
分子量：4329.90
纯度：>95% by HPLC
盐：三氟乙酸(Trifluoroacetic acid,TFA)
来源：化学合成

Scrambled-Beta-Amyloid (1-40)序列分析：

引用文献：

Cerebrospinal fluid A beta 1–40 peptides increase in Alzheimer’s disease and are highly correlated with phospho-tau in control individuals

Sylvain Lehmann
Julien Dumurgier,
Xavier Ayrignac,
Cecilia Marelli,
Daniel Alcolea,
Juan Fortea Ormaechea,
Eric Thouvenot,
Constance Delaby,
Christophe Hirtz,
Jérôme Vialaret,
Nelly Ginestet1,
Elodie Bouaziz-Amar,
Jean-Louis Laplanche,
Pierre Labauge,
Claire Paquet,
Alberto Lleo &
Audrey Gabelle

Alzheimer's Research & Therapy. Volume 12, article number 123, (2020)

 

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