肿瘤靶向肽 iRGD peptide环肽 1392278-76-0 c(CRGDKGPDC)

RGD环肽

c(CRGDKGPDC)，iRGD peptide

1392278-76-0

结    构    式：

 H2N-CRGDKGPDC-OH(Disulfide Bridge:C1-C9)

 H2N-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-COOH(Disulfide Bridge:Cys1-Cys9)

氨基酸个数：  9

 C35H57N13O14S2

平均分子量:  948.04

精确分子量:  947.36

等电点(PI):  8.83

pH=7.0时的净电荷数: 1.91

平均亲水性: 1.6666666666667

疏水性值:  -1.42

外观与性状: 粉末状固体

体内研究：iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体外研究：iRGD peptide-mediated tumor penetration occurs in three steps: binding to αv-integrins on tumor vasculature or tumor cells, exposure by proteolysis of a C-terminal motif that binds to neuropilin-1 (NRP-1) and cell internalization. iRGD peptide inserted in the ICOVIR15K fiber C terminus enhances binding and internalization only in MCF7 cells, which express NRP-1 and integrins. iRGD insertion does not impair virus infection and replication[1]. iRGD peptide alone has no obvious effect on gastric cancer cells, and when combined with 5-FU, iRGD peptide (0.3 μmol/mL) enhances the chemotherapy efficacy of 5-FU on gastric cancer cells through NRP1[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.