[paper]多示例学习在病理图像分类中的应用

Multiple Instance Learning with Center Embedding for Histopathology Classification

Year: 2020, Author: Philip Chikontwe, Meejeong Kim, Sang Hyun Park et al.

Journal Name: MICCAI

1. Background

• Histopathology images play a vital role as a gold standard for cancer diagnosis in clinical settings.
• Pixel-level annotations are difficult, time-consuming and costly to acquire.

2. Problems & Solutions

• Problems

  • Instance labels in MIL is ambiguity and learning robust instance embeddings is also challenging. Some approach often fails when learning based on noisy labels.

• Solutions

  • Use an end-to-end framework that exploits instance- & bag-level representations.

3. Methods

• Overview of the proposed framework

• Notes

4. Experiments

Dataset

• Two colectoral cancer (CRC) WSI datasets involve H&E stained.
• Dataset Ⅰ consists of 173 WSIs (59 normal & 114 MSI).
• Dataset Ⅱ consists of 193 WSIs (85 normal & 108 MSI).
• 40% training, 10% validation, 50% testing.

Evalution Metrics

• Use Ostu method.
• https://blog.csdn.net/qq_29462849/article/details/81022607

Settings

• Set top-k instance selection to 50 and used instances with 256 X 256 size.
• Use finetuned ResNet-34 as the feature extraction model F_θ (·).
• Fully Conected (FC) layers as the instance and bag classifiers H_I and H_B.
• The feature dimension of the embeddings and center model was set to 512.
• Learning rate = 1e-4, #epoch = 40.
• Loss hyperparameters λ = 0.01, α = 1.0, β = 0.01.

5. Results

• Comparision Methods

• Qualitative Results

• Segmentation Results

6. Contributions

• Propose an end-to-end framework for wekly superwised histopathology classification to assign correct instance and bag labels.
• Show that center loss can improve bag features learning and also reduce ambiguity in instance labels.
• Propose a soft-assignment based inference method for bag-level prediction with overal improved performance over recent SOTA methods.