Ivabradine (hydrochloride) | 盐酸伊伐布雷定 _ MedChemExpress (MCE)

中文名：盐酸伊伐布雷定

CAS：148849-67-6

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture

生物活性：Ivabradine hydrochloride 是一种有效的口服活性HCN（超极化激活环核苷酸门控）通道阻滞剂，可抑制心脏起搏器电流 (If)。 Ivabradine hydrochloride 在不改变血压的情况下降低剂量依赖性心率。盐酸伊伐布雷定具有抗惊厥、抗缺血和抗心绞痛作用[1][2][3][4] 。 

体内：Ivabradine hydrochloride (1, 10, 20 mg/kg; ip) 在小鼠体内表现出抗惊厥和神经保护作用[3]。
Ivabradine hydrochloride (5, 10, 20 mg/kg; po;每天一次，持续 1 周）降低交感肾上腺素能活动增强的小鼠的心率[4]。

 参考详情：https://www.medchemexpress.com/ivabradine-hydrochloride.html

参考文献：

[1]. Tardif JC, et al. Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26(23):2529-36.

[2]. Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 2006;43:97-105.

[3]. Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan;109:2499-2512.

[4]. Du XJ, et al. I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142(1):107-12.