这种生物素化的载脂蛋白抑制剂已成功地用于在链霉亲和素琼脂糖柱上亲和纯化半胱氨酸蛋白酶-3(载脂蛋白),即裂解聚(ADP核糖)聚合酶(PARP)的酶。生物素DEVD CHO显示出与N-乙酰化类似物抑制剂(H-2496)相当的抑制活性(IC₅₀ = 0.2nM)。
This biotinylated apopain inhibitor has successfully been used for the affinity purification - on a streptavidin-agarose column - of caspase-3 (apopain), the enzyme that cleaves the poly(ADP-ribose) polymerase (PARP). Biotinyl-DEVD-CHO showed an inhibitory activity comparable to that of the N-acetylated analog inhibitor (H-2496) (IC₅₀ = 0.2 nM).
编号: 159576
中文名称: 生物素标记肽Biotin-DEVD-醛基化
英文名: Biotin-Asp-Glu-Val-Asp-CHO
CAS号: 178603-73-1
单字母: Biotin-DEVD-CHO
三字母: Biotin-Asp-Glu-Val-Asp-CHO
氨基酸个数: 4
分子式: C28H42N6O12S1
平均分子量: 686.73
精确分子量: 686.26
等电点(PI): -
pH=7.0时的净电荷数: -3
平均亲水性: 1.875
疏水性值: -1.58
来源: 人工化学合成,仅限科学研究使用,不得用于人体。
纯度: 95%、98%
盐体系: 可选TFA、HAc、HCl或其它
储存条件: 负80℃至负20℃
标签: 生物素标记肽(Biotinyl) 醛肽 抑制剂相关肽 凋亡与坏死
相关文献:
DOI 名称
10.1038/376037a0 Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis 下载
10.1016/s0167-4838(02)00333-3 Probing the caspase-3 active site by fluorescence lifetime measurements 下载
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