MCE 国际站:Lanosterol
中文名:羊毛甾醇
CAS:79-63-0
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:羊毛甾醇是胆固醇合成的中间体,羊毛甾醇的使用会诱导胆固醇合成速率控制酶(即 HMG CoA 还原酶)的泛素化和降解。羊毛甾醇抑制与神经退行性疾病相关的错误折叠蛋白的聚集和细胞毒性[1][2]。
体外:羊毛甾醇通过诱导表达辅助伴侣 CHIP 和提高自噬来减少异常蛋白毒性聚集并减轻其细胞毒性[1]。
羊毛甾醇是胆固醇生物合成途径中减数分裂激活甾醇的前体,并且诱导指示卵母细胞重新启动减数分裂的生理信号[2]。
热销产品:4-P-PDOT | Sparsentan | Gemtuzumab | Istradefylline | Surfen (dihydrochloride) | Idelalisib | GDP-L-fucose | (-)-Securinine | Glyoxalase I inhibitor 3 | L-Isoleucine
研究领域:Metabolic Enzyme/Protease
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:
[1]. Upadhyay A, et al. Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Mol Neurobiol. 2018;55(2):1169-1182.
[2]. Lee S, et al. Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. Theriogenology. 2016;85(4):575-584.