中文名:碘海醇
CAS:66108-95-0
品牌:MedChemExpress (MCE)
存储条件:4°C, protect from light
生物活性:碘海醇是一种射线照相造影剂,可用于脊髓造影、计算机断层扫描?(脑池造影、脑室造影)和显微 CT 成像体内[1] .
体外:Iohexol (150 mg I/mL, 0-24 h) 抑制 NRK 52-E 的细胞活力[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内:Iohexol (0.25-4 mL/kg, p.o., weekly) 浓度为 0.5-2.0 mL/kg 时,可促进狗肠段的分化[4]。 Iohexol (64.7 mg/kg,静脉注射) 可用于估算健康或患有慢性肾病 (CKD) 的犬的肾小球滤过率 (GFR)[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Healthy dogs [4] Dosage: 0.25-4 mL/kg Administration: Oral gavage (p.o.), weekly Result: Peaked the iohexol serum concentrations between 2 and 4 hours. Reduced radiolucency after application of 0.25 mL/kg and 4 mL/kg. Included watery diarrhea after ingestion of 4 mL/kg. Clinical Trial
参考详情:https://www.medchemexpress.com/iohexol.html
参考文献:
[1]. Hainfeld JF, Ridwan SM, Stanishevskiy Y, Smilowitz NR, Davis J, Smilowitz HM. Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging. Sci Rep. 2018 Sep 14;8(1):13803.
[2]. Soman RS, et al. Development and validation of an HPLC-UV method for determination of iohexol in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):339-43.
[3]. Jensen H, et al. The effects of the iodinated X-ray contrast media iodixanol, iohexol, iopromide, and ioversol on the rat kidney epithelial cell line NRK 52-E. Ren Fail. 2011;33(4):426-33.
[4]. Klenner S, et al. Estimation of intestinal permeability in healthy dogs using the contrast medium iohexol. Vet Clin Pathol. 2009 Sep;38(3):353-60.
[5]. Baklouti S, et al. Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time. Front Pharmacol. 2021 Apr 29;12:634404.