中文名:1-脱氧野尻霉素
CAS:19130-96-2
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:1-Deoxynojirimycin (Duvoglustat) 是一种有效的口服活性 α-葡萄糖苷酶 抑制剂。 1-Deoxynojirimycin 可抑制餐后血糖,广泛用于糖尿病。 1-Deoxynojirimycin 具有抗高血糖、抗肥胖和抗病毒作用[1][2]。
体内:1-Deoxynojirimycin (Duvoglustat)(20-80 mg/kg;iv;每日一次,持续 4 周)显示抗肥胖作用[3]。1-Deoxynojirimycin 通过激活显着改善胰岛素敏感性db/db小鼠骨骼肌胰岛素信号通路PI3K/AKT[3]。
参考详情:https://www.medchemexpress.com/1-Deoxynojirimycin.html
热销产品:9-Aminocamptothecin | SJB2-043 | Lemzoparlimab | [D-p-Cl-Phe6,Leu17]-VIP (TFA) | Apratastat | Norwogonin | Malate dehydrogenase | GSK-J2 | L-Alpha-Lysophosphatidylcholine,oleoyl-d7 | Saikosaponin B2
研究领域:Metabolic Enzyme/Protease | PI3K/Akt/mTOR
作用靶点:Glucosidase | PI3K
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:
[1]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232
[2]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600.
[3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14.