CAS:30868-30-5
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:Pyrazofurin 是一种具有抗肿瘤活性的嘧啶核苷类似物,通过抑制 uridine 5'-phosphate (UMP) 合酶[1] 抑制细胞增殖和细胞内 DNA 合成。 Pyrazofurin 是一种活性、敏感的乳清酸磷酸核糖基转移酶抑制剂,在三种鳞状细胞癌 (SCC) 细胞中的 IC50 介于 0.06-0.37 μM 之间线 Hep-2、HNSCC-14B 和 HNSCC-14C[2]。
参考详情:https://www.medchemexpress.com/pyrazofurin.html
参考文献:
[1]. Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6(1):19-27.
[2]. Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):329-339.