time-to-event数据的参考资料

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分类专栏：统计学文章标签：笔记

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23 篇文章 5 订阅

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一、书籍推荐

二、方法论文章

Introductory/Overview Articles

Censoring

Non-parametric survival methods

Semi-parametric survival methods

Parametric survival methods

Time-Varying Covariates

Competing risk analysis

Analysis of clustered data and frailty models

Recurrent Event Analysis

一、书籍推荐

Vittinghoff E, Glidden DV, Shiboski SC, McCulloch CE (2012). Regression Methods in Biostatistics, 2nd New York, NY: Springer.

线性模型、逻辑模型、生存模型和重复测量模型的入门教材，最适合希望获得基本入门知识的读者。
生存分析一章提供了很好的概述，但不深入。示例基于 STATA。

Hosmer DW, Lemeshow S, May S. (2008) Applied Survival Analysis: Regression Modeling of Time-to-Event Data, 2nd ed. Hoboken, NJ: John Wiley & Sons, Inc.

对非参数、半参数和参数 Cox 模型进行了深入概述，最适合对统计学的其他领域有所了解的读者。高级技术未作深入介绍，但提供了其他专业教科书的参考资料。

Kleinbaum DG, Klein M (2012). Survival Analysis: A Self-Learning Text, 3rd ed. New York, NY: Springer Science + Business Media, LLC

出色的入门读物

Klein JP, Moeschberger ML (2005). Survival Analysis: Techniques for Censored and Truncated Data, 2nd ed. New York, NY: Springer Science + Business Media, LLC

本书专为研究生设计，提供了许多实用范例

Therneau TM, Grambsch PM (2000). Modeling Survival Data: Extending the Cox Model. New York, NY: Springer Science + Business Media, LLC

很好地介绍了计数过程方法和相关生存数据分析。作者还用 R 编写了 "生存 "软件包

Allison PD (2010). Survival Analysis Using SAS: A Practice Guide, 2nd ed. Cary, NC: SAS Institute

为 SAS 用户提供的优秀应用文本

Bagdonavicius V, Nikulin M (2002). Accelerated Life Models: Modeling and Statistical Analysis.Boca Raton, FL: Chapman & Hall/CRC Press.

关于参数和半参数加速故障时间模型及其与比例风险模型比较的更多信息的良好资源。

二、方法论文章

Introductory/Overview Articles

Hougaard P (1999). Fundamentals of Survival Data. Biometrics 55(1): 13-22. PMID:11318147(link is external and opens in a new window).

Clark TG, Bradburn MJ, Love SB, Altman DG (2003). Survival analysis part I: basic concepts and first analyses. Br J Cancer 89(2): 232-8. PMID: 12865907(link is external and opens in a new window)

Clark TG, Bradburn MJ, Love SB, Altman DG (2003). Survival analysis part II: multivariate data analysis–an introduction to concepts and methods. Br J Cancer 89(3): 431-6. PMID:1288808(link is external and opens in a new window)

Clark TG, Bradburn MJ, Love SB, Altman DG (2003). Survival analysis part II: multivariate data analysis–choosing a model and assessing its adequacy and fit. Br J Cancer 89(4): 605-11. PMID: 12951864(link is external and opens in a new window)

Clark TG, Bradburn MJ, Love SB, Altman DG (2003). Survival analysis part IV: further concepts and methods in survival analysis. Br J Cancer 89(5): 781-6. PMID: 12942105(link is external and opens in a new window)

上述四篇系列文章是对生存分析方法的极佳入门概述，文笔极佳，通俗易懂--强烈推荐。

Censoring

Huang CY, Ning J, Qin J (2015). Semiparametric likelihood inference for left-truncated and right-censored data. Biostatistics [epub] PMID: 25796430(link is external and opens in a new window).

本文很好地介绍了删失数据的分析，并提供了一种新的左截断和右删失数据的生存时间分布估计程序。它非常密集，并且具有先进的统计重点。

Cain KC, Harlow SD, Little RJ, Nan B, Yosef M, Taffe JR, Elliott MR (2011). Bias due to left truncation and left censoring in longitudinal studies of developmental and disease processes. Am J Epidemiol 173(9):1078-84. PMID: 21422059(link is external and opens in a new window).

这是一本从流行病学角度解释左删失数据固有偏差的优秀资料。

Sun J, Sun L, Zhu C (2007). Testing the proportional odds model for interval-censored data.Lifetime Data Anal 13:37–50. PMID 17160547(link is external and opens in a new window).

这是另一篇统计内容密集的文章，涉及 TTE 数据分析的一个细微方面，但对区间删失数据进行了很好的解释。

Robins JM (1995a) An analytic method for randomized trials with informative censoring: Part I. Lifetime Data Anal 1: 241–254. PMID 9385104(link is external and opens in a new window).

Robins JM (1995b) An analytic method for randomized trials with informative censoring: Part II. Lifetime Data Anal 1: 417–434. PMID 9385113(link is external and opens in a new window).

两篇论文讨论了处理信息删失的方法。

Non-parametric survival methods

Borgan Ø (2005) Kaplan-Meier Estimator. Encyclopedia of Biostatistics DOI: 10.1002/0470011815.b2a11042

对 Kaplan-Meier 估计及其与 Nelson-Aalen 估计关系的精彩概述。

Rodríguez G (2005). Non-Parametric Estimation in Survival Models. Available from:http://data.princeton.edu/pop509/NonParametricSurvival.pdf(link is external and opens in a new window)

介绍非参数方法和考克斯比例危险模型，用数学公式解释各种方法之间的关系。

Cole SR, Hernan MA (2004). Adjusted survival curves with inverse probability weights.Comput Methods Programs Biomed 75(1): 35-9. PMID: 15158046(link is external and opens in a new window)

本文详细描述了利用逆概率加权（IPW）方法创建调整后的Kaplan-Meier曲线，同时提供了一个实例和SAS宏。

Zhang M (2015). Robust methods to improve efficiency and reduce bias in estimating survival curves in randomized clinical trials. Lifetime Data Anal 21(1): 119-37. PMID:24522498(link is external and opens in a new window)

Semi-parametric survival methods

Cox DR (1972) Regression models and life tables (with discussion). J R Statist Soc B 34: 187–220.

经典参考。

Christensen E (1987) Multivariate survival analysis using Cox’s regression model.Hepatology 7: 1346–1358. PMID 3679094(link is external and opens in a new window).

通过一个生动的例子介绍了 Cox 模型的使用。出色地回顾了 Cox 模型分析的主要方面，包括如何拟合 Cox 模型和检查模型假设。

Grambsch PM, Therneau TM (1994) Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81: 515–526.

关于比例危险假设检验的深度论文。理论与高级统计解释结合得很好。

Ng’andu NH (1997) An empirical comparison of statistical tests for assessing the proportional hazards assumption of Cox’s model. Stat Med 16: 611–626. PMID 9131751(link is external and opens in a new window).

这是另一篇关于检验比例危险假设的深度论文，其中讨论了检查残差和删失的影响。

Parametric survival methods

Rodrίguez, G (2010). Parametric Survival Models. Available from:http://data.princeton.edu/pop509/ParametricSurvival.pdf(link is external and opens in a new window)

简要介绍参数生存分析中最常用的分布。

Nardi A, Schemper M (2003). Comparing Cox and parametric models in clinical studies.Stat Med 22 (23): 2597-610. PMID: 14652863(link is external and opens in a new window)

提供了将半参数模型与使用常见参数分布的模型进行比较的良好示例，并重点评估模型拟合度。

Royston P, Parmar MK (2002). Flexible parametric proportional-hazards and proportional-odds models for censored survival data, with application to prognostic modelling and estimation of treatment effects. Stat Med 21(15): 2175-97. PMID: 12210632(link is external and opens in a new window)

很好地解释了PH风险和PO模型的基础知识以及与三次样条的比较。

Cox C, Chu H, Schneider MF, Muñoz A (2007). Parametric survival analysis and taxonomy of hazard functions for the generalized gamma distribution. Statist Med 26:4352–4374. PMID 17342754(link is external and opens in a new window).

该书出色地概述了参数生存方法，包括危害函数分类法和广义伽马分布系列的深入讨论。

Crowther MJ, Lambert PC (2014). A general framework for parametric survival analysis.Stat Med 33(30): 5280-97. PMID: 25220693(link is external and opens in a new window)

介绍常用参数分布的限制性假设，并解释限制性三次样条法。

Sparling YH, Younes N, Lachin JM, Bautista OM (2006). Parametric survival models for interval-censored data with time-dependent covariates. Biometrics 7 (4): 599-614. PMID:16597670(link is external and opens in a new window)

如何使用参数模型处理区间删失数据的扩展和示例。

Time-Varying Covariates

Fisher LD, Lin DY (1999). Time-dependent covariates in the Cox proportional-hazards regression model. Annu Rev Public Health 20: 145-57. PMID: 10352854(link is external and opens in a new window)

深入浅出地解释了 Cox 模型中的时变协变量，并附有数学附录。

Petersen T (1986). Fitting parametric survival models with time-dependent covariates. Appl Statist 35(3): 281-88.

文章较长，但有一个有用的应用实例

Competing risk analysis

See Competing Risks

Tai B, Machin D, White I, Gebski V (2001) Competing risks analysis of patients with osteosarcoma: a comparison of four different approaches. Stat Med 20: 661–684. PMID11241570(link is external and opens in a new window).

这篇深入浅出的论文介绍了分析竞争风险数据的四种不同方法，并利用骨肉瘤患者随机试验的数据对这四种方法进行了比较。

Checkley W, Brower RG, Muñoz A (2010). Inference for mutually exclusive competing events through a mixture of generalized gamma distributions. Epidemiology 21(4): 557–565. PMID 20502337(link is external and opens in a new window).

关于使用广义伽马分布的竞争风险的论文。

Analysis of clustered data and frailty models

Yamaguchi T, Ohashi Y, Matsuyama Y (2002) Proportional hazards models with random effects to examine centre effects in multicentre cancer clinical trials. Stat Methods Med Res 11: 221–236. PMID 12094756(link is external and opens in a new window).

这篇论文从理论和数学角度对分析多中心临床试验的生存数据时如何考虑聚类问题进行了出色的解释。

O’Quigley J, Stare J (2002) Proportional hazards models with frailties and random effects. Stat Med 21: 3219–3233. PMID 12375300(link is external and opens in a new window).

脆弱模型与随机效应模型的正面比较。

Balakrishnan N, Peng Y (2006). Generalized gamma frailty model. Statist Med 25:2797–2816. PMID

用广义伽玛分布作为脆弱分布，研究了脆弱性模型。

Rondeau V, Mazroui Y, Gonzalez JR (2012). frailtypack: An R Package for the Analysis of Correlated Survival Data with Frailty Models Using Penalized Likelihood Estimation or Parametrical Estimation. Journal of Statistical Software 47(4): 1-28.

R 软件包 vignette 提供了有关脆弱模型的大量背景信息。

Schaubel DE, Cai J (2005). Analysis of clustered recurrent event data with application to hospitalization rates among renal failure patients. Biostatistics 6(3):404-19. PMID15831581(link is external and opens in a new window).

作者在这篇优秀论文中介绍了两种分析聚类重复事件数据的方法，然后将所提模型的结果与基于脆弱模型的结果进行了比较。

Gharibvand L, Liu L (2009). Analysis of Survival Data with Clustered Events. SAS Global Forum 2009 Paper 237-2009.

简明易懂的资料来源，用于使用 SAS 程序分析带有聚类事件的事件时间数据。

Recurrent Event Analysis

Twisk JW, Smidt N, de Vente W (2005). Applied analysis of recurrent events: a practical overview. J Epidemiol Community Health 59(8): 706-10. PMID: 16020650(link is external and opens in a new window)

非常通俗易懂地介绍了复发事件建模和风险集的概念。

Villegas R, Juliá O, Ocaña J (2013). Empirical study of correlated survival times for recurrent events with proportional hazards margins and the effect of correlation and censoring.BMC Med Res Methodol 13:95. PMID: 23883000(link is external and opens in a new window)

使用模拟来测试不同模型对复发事件数据的稳健性。

Kelly PJ, Lim LL (2000). Survival analysis for recurrent event data: an application to childhood infectious diseases. Stat Med 19 (1): 13-33. PMID: 10623190(link is external and opens in a new window)

四种主要方法对复发事件数据建模的应用实例。

Wei LJ, Lin DY, Weissfeld L (1989). Regression analysis of multivariate incomplete failure time data by modeling marginal distributions. Journal of the American Statistical Association84 (108): 1065-1073