exon ,UTR, ORF与 CDS
UTRs: untranslated region introns
CDS: Sequence coding for amino acids in protein.A contiguous sequence which begins with, and includes, a start codon and ends with, and includes, a stop codon.
Exon: A region of the transcript sequence within a gene which is not removed from the primary RNA transcript by RNA splicing.
ORF:Open reading frame
Exon contains both of UTR and CDS. The CDS is the sequence that actually makes proteins.
pre mRNA, mature mRNA
UTR: 成熟mRNA 位于编码区(CDS)上下游的不翻译为蛋白质的区域。
exon包括CDS和UTR
ORF:从一个起始密码子开始到一个终止密码子结束的序列;但不是所有ORF都能表达出蛋白产物或具有生物学功能的蛋白产物。ORF不一定是CDS。
CDS:编码蛋白产物,一定是一个ORF,也可能包括多个ORF。
Alternative splicing选择性剪接:
mRNA前体通过不同的剪接方式产生不同的mRNA剪接异构体,产生结构或功能各异的最终蛋白产物。