AbMole| Donanemab 多奈/多纳单抗（CAS号：1931944-80-7）

Donanemab 多奈/多纳单抗 Donanemab (LY3002813) 是一种针对 N 末端焦谷氨酸β淀粉样蛋白 (Aβ) 表位的人源化 IgG1κ 单克隆抗体。能通过与淀粉样蛋白N3pG亚型特异性结合，从而促进淀粉样斑块的清除。可用于阿尔茨海默病（AD）的相关研究。

1.化学性质

CAS号	1931944-80-7
储存条件	Please store the product under the recommended conditions in the Certificate of Analysis.
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

 2.参考文献

[1] Michael J Pontecorvo, et al. JAMA Neurol. Association of Donanemab Treatment With Exploratory Plasma Biomarkers in Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ Randomized Clinical Trial

[2] Sergey Shcherbinin, et al. JAMA Neurol. Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial

[3] Eric L Ross, et al. JAMA Neurol. Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US

[4] Mark A Mintun, et al. N Engl J Med. Donanemab in Early Alzheimer's Disease

[5] Stephen Loucian Lowe, et al. Alzheimers Dement (N Y). Donanemab (LY3002813) dose-escalation study in Alzheimer's disease