L-Alanosine | 丙氨菌素 _ MedChemExpress (MCE)

中文名：丙氨菌素

CAS：5854-93-3

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years.

生物活性：L-Alanosine (NSC-153353) 是一种来自 Streptomyces alanosinicus 的抗生素，具有抗肿瘤活性。 L-Alanosine (NSC-153353) 抑制腺苷酸合成酶，后者将肌苷单磷酸 (IMP) 转化为腺苷酸。 L-Alanosine (NSC-153353) 阻断常见的嘌呤从头生物合成途径，从而抑制 MTAP 缺陷的肿瘤细胞[1][2][ 3]。

 参考详情：L-Alanosine (NSC-153353，丙氨菌素) - 仅供科研 | 抗生素和抗肿瘤剂 | MCE

参考文献：

[1]. Efferth T, et al. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Biochem Pharmacol. 2003 Aug 15;66(4):613-21.

[2]. Chitnis MP, et al. Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias. Tumori. 1984 Aug 31;70(4):317-20.

[3]. Tyagi AK, et al. Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase. Cancer Res. 1980 Dec;40(12):4390-7.