Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex
Tobias Rose,* Juliane Jaepel, Mark Hübener, Tobias Bonhoeffer*
Max Planck Institute of Neurobiology, Germany
《Science》 2016
摘要
背景是蒙住一只眼,大脑视觉皮层会适应只有一只眼的情况,当恢复两只眼后,大脑视觉皮层再次跟着恢复。本文探索研究恢复过程中单个神经元的变化,及其对群体神经元的影响。
之前的研究
做视觉皮层的挺多的,但是由于技术限制,不能长时程追踪单个神经元活动,It is therefore not yet clear how individual neurons shift their functional properties in response to prolonged perturbations of sensory input, andwhether their initial stimulus selectivity is lost or maintained after recovery。用ratiometric Ca2+ imaging以及GCaMP6s蛋白解决了这个问题。然后,这篇文章研究了单个神经元的特性,在单眼剥夺阶段,恢复双眼阶段,以及再次单眼剥夺阶段。共计2个月。一只26个cell,另一只12个cell。文中说8只动物133个cell,总计多少只?反正最大统计了828个cell。
通过各种指标(例如ODI等)来表征变化程度,得到了文章标题的结果。
讨论
It is tempting to speculate that these connections remain stable even under conditions of a changing sensory environment, whereas the majority of weak synapses provide the substrate for reversible plastic modifications (28, 30). 作者认为weak连接的保存是功能恢复提供了可能