ISO-1
CAS:478336-92-4
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性:ISO-1 是一种巨噬细胞迁移抑制因子 (MIF) 拮抗剂,IC50 为 7 μM。 IC50 和目标:IC50:7 μM (MIF)[1]
体外:ISO-1 (0.1-20 μM; 16 hours) 在不添加重组 MIF[1] 的情况下对 Cox-2 分泌有轻微的抑制作用。
体内:ISO-1(腹膜内注射;3.5-35 mg/kg;每日两次;2 周)可提高致死性内毒素血症的存活率并显示出抗炎作用[2]。
ISO -1(腹膜内注射;35 mg/kg;每天两次;3 天)导致植入物平均尺寸显着减小并降低植入物中的 Flk1 表达[3]。
参考文献:
[1]. Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.
[2]. Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280(44):36541-4.
[3]. Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3(3):135-142.