L-精氨酸 是内皮一氧化氮合酶 (eNOS) 生成 NO 的底物 | MedChemExpress (MCE)

L-Arginine

中文名：L-精氨酸

CAS：74-79-3

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：L-精氨酸 ((S)-(+)-Arginine) 是内皮一氧化氮合酶 (eNOS) 生成 NO 的底物。 L-精氨酸通过蛋白质的阳离子氨基酸转运蛋白家族转运到血管平滑肌细胞，在那里它被代谢为一氧化氮 (NO)、多胺或 L-脯氨酸[1][ 2]。

体内：L-Arginine 可用于动物建模，构建动物胰腺炎模型。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献：

[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.
[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.
[3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.