DEHP（双（2-乙基己基）邻苯二甲酸酯）是一种内源性代谢物。|MedChemExpress (MCE)

CAS：117-81-7

品牌：MedChemExpress (MCE)

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生物活性： DEHP（双（2-乙基己基）邻苯二甲酸酯）是一种内源性代谢物。

体外：DEHP (0-160 µM, 48 h) 显著抑制了小鼠 GC-1 spg 细胞的细胞活力[1]。 DEHP (0-160 µM, 48 h) 通过氧化应激诱导小鼠 GC-1 spg 细胞自噬和凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：DEHP (0-500 mg/kg, 口服, 每日一次, 8 周) 会损害雌性 C3H/N 小鼠的生育能力[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C3H/N mice[1] Dosage: 0-500 mg/kg Administration: p.o., daily, 8 weeks Result: Increased the body weight and visceral fat tissue. Increased the expression of PPARα and PPARγ mRNA at the dose of 500 mg/kg. Decreased mRNA expression of PPARα transcripts/106 18S molecules at the dose of 500 mg/kg. Reduced the level of adiponectin mRNA. Increased the mRNA concentration of FABP4 at the dose of 0.05 mg/kg.

参考详情：https://www.medchemexpress.com/bis-2-ethylhexyl-phthalate.html