Metabolic dependencies drive species co-occurrence in diverse microbial communities
PNAS 2015 9+
European Molecular Biology Laboratory
Points:
使用了800 communities进行ModelSEED pipeline得到resource competition and metabolic exchanges
发现在多种群落中存在metabolically interdependent groups
列举co-occurring subcommunities中的flux-balanced metabolic exchanges,预测可能存在交换的代谢物
结论:代谢依赖是造成物种共存的主要驱动
co-occurring subcommunities
Fisher’s exact test, false discovery rate (FDR) 0.01
群落中物种门内及门间关系
代谢模型构建
单物种代谢模型重构:ModelSEED pipline,用mixed-integer linear programming (MILP)校正
多物种代谢模型构建:参考文献