高速三维成像与计算显微成像
Imaging devices in the healthcare sector have played a pivotal role in the diagnosis and the eventual treatment of different conditions, but this recent innovation is no less than a breakthrough one. Researchers from the University of Adelaide (Australia) and the University of Stuttgart (Germany) have developed the world’s smallest imaging device — measuring in at the thickness of a human hair.
在医疗行业我 maging设备都起到诊断和不同条件下的最终处理了举足轻重的作用，但这种新的创新比突破一个也不能少。 来自阿德莱德大学(澳大利亚)和斯图加特大学(德国)的研究人员开发了世界上最小的成像设备-以人发的厚度进行测量。
Despite the recent advances by which high-end resolution endoscopes have become an indispensable clinical tool, there is still a need for miniaturized high-resolution probes that could provide high-resolution images in addition to depth of focus — eventually proving extremely useful in the prevention and treatment of various medical conditions.
尽管高端分辨率内窥镜已成为不可或缺的临床工具，但最近仍取得了进展，但仍需要微型化的高分辨率探头，这些探头除了可以提供聚焦深度以外，还可以提供高分辨率的图像-最终证明在预防中极为有用和各种医疗条件的治疗。
This camera-like imaging device proved its usefulness in trials traveling down the blood vessels of mice — offering unprecedented abilities to 3D-scan the body at microscopic resolutions. The revolutionary device would help the doctors specifically in better understanding the causes of heart attack and heart disease progression.
这款类似相机的成像设备证明了其在沿着小鼠血管行进的试验中的有用性-提供了前所未有的以显微分辨率对人体进行3D扫描的功能。 革命性的设备将特别有助于医生更好地了解心脏病发作和心脏病发展的原因。
“Until now, we couldn’t make high-quality endoscopes this small. Using 3D micro-printing, we are able to print complicated lenses that are too small to see with the naked eye. The entire endoscope, with a protective plastic casing, is less than half a millimeter across. ”
“到目前为止，我们还不能将如此小的高质量内窥镜制造得如此之小。 使用3D微打印，我们可以打印太小的肉眼无法看到的复杂镜头。 带有保护性塑料外壳的整个内窥镜的直径小于半毫米。 ”
~ Dr. Simon Thiele, Study Lead
〜研究主管Simon Thiele博士
Current fabrication techniques used to develop limit the imaging performance of highly miniaturized probes, thus limiting their widespread application. For this miniature probe, the researchers utilized a novel technique of 3D microprinting to reliably create side-facing freeform micro-optics (<130 µm diameter) on single-mode fibers.
用于开发的当前制造技术限制了高度小型化的探针的成像性能，因此限制了它们的广泛应用。 对于这种微型探针，研究人员利用3D微打印的新技术，在单模光纤上可靠地创建了侧面自由形式的微光学元件(直径<130 µm)。
The end result was a fully functional ultrathin aberration-corrected optical coherence tomography probe — the smallest freeform 3D imaging probe yet with a diameter of 0.457 mm (0.02 in). The capabilities of the device were tested in the trials conducted by imaging atherosclerotic human and mouse arteries.
最终结果是功能齐全的超薄像差校正光学相干断层扫描探头-最小的自由形式3D成像探头，直径为0.457毫米(0.02英寸)。 在对动脉粥样硬化性人和小鼠动脉成像进行的试验中测试了该设备的功能。
An optical coherence tomography (OCT) scanner was connected to the optical fiber. OCT is basically a 3D depth-sensitive scanning technology, commonly used to map the retina in optometry and ophthalmology. The technology uses near-infrared light to penetrate into tissue — measuring the wave interference between a reference beam and a probe beam to build up live 3D images that can look through surfaces within the body into the structures beneath at microscopic resolutions.
光学相干断层扫描(OCT)扫描仪连接到光纤。 OCT基本上是一种3D深度敏感扫描技术，通常用于在验光和眼科中绘制视网膜图。 该技术使用近红外光穿透组织-测量参考光束和探测光束之间的波干扰，以建立实时3D图像，该图像可以以微观分辨率透过体内的表面直视下方的结构。
Most important of all, the OCT scanning device can be pushed through blood vessels in the body. The ultra-thin nature & flexibility of the probe let it build up a 3D map of its surroundings to a depth around half a millimeter below the surface. The team believes the new device can not only offer high-resolution images at the cellular level but also allow the scanner to image depths five times deeper than previous attempts.
最重要的是，OCT扫描设备可以推入体内的血管。 探头的超薄特性和灵活性使其可以在周围表面以下深度约半毫米处构建周围环境的3D地图。 研究小组认为，新设备不仅可以提供蜂窝级别的高分辨率图像，还可以使扫描仪的图像深度比以前的尝试高五倍。
Complete Research was published in the journal Light Science & Applications.
《完整研究》 发表在《 光科学与应用 》杂志上。
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高速三维成像与计算显微成像
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