python图像计数,使用python中的图像处理对粒子进行计数

Is there any good algorithm for detecting particles on a changing background intensity?

For example, if I have the following image:

Is there a way to count the small white particles, even with the clearly different background that appears towards the lower left?

To be a little more clear, I would like to label the image and count the particles with an algorithm that finds these particles to be significant:

I have tried many things with the PIL, cv , scipy , numpy , etc. modules.

I got some hints from this very similar SO question, and it appears at first glance that you could take a simple threshold like so:

im = mahotas.imread('particles.jpg')

T = mahotas.thresholding.otsu(im)

labeled, nr_objects = ndimage.label(im>T)

print nr_objects

pylab.imshow(labeled)

but because of the changing background you get this:

I have also tried other ideas, such as a technique I found for measuring paws, which I implemented in this way: