FastTree infers approximately-maximum-likelihood phylogenetic trees from alignments of
nucleotide or protein sequences. FastTree can handle alignmentswith up to a million
of sequencesin a reasonable amount of time and memory. For large alignments, FastTree
is 100-1,000 times faster thanPhyML 3.0orRAxML 7. FastTree is open-source software -- you
can download the codebelow.
FastTree is more accurate than PhyML 3 with default settings,
andmuch more accurate than the distance-matrix methodsthat are
traditionally used for large alignments. FastTree uses the Jukes-Cantor or generalized time-
reversible (GTR) models of nucleotide evolution and the JTT (Jones-Taylor-Thornton 1992) model
of amino acid evolution. To account for the varying rates of evolution across sites, FastTree
uses a single rate for each site (the "CAT" approximation). To quickly estimate the
reliability of each split in the tree, FastTree computes local support values with
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