Niacin | 烟酸 _ MedChemExpress (MCE)

MCE 国际站：Niacin

参考详情：Niacin (Nicotinic acid，烟酸) - 仅供科研 | B3维生素 | MCE

中文名：烟酸

CAS：59-67-6

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：烟酸（维生素 B3）是一种具有口服活性的水溶性 B3 维生素，是人类必需的营养素。烟酸（维生素 B3）在能量代谢、调节基因表达的细胞信号级联反应和细胞凋亡中起着关键作用。烟酸（维生素 B3）也用于心血管疾病的研究[1][2]。

体外：烟酸（0-900 μM，42小时）显着增加GSH水平，降低ROS水平，影响细胞凋亡和脂质代谢相关基因的表达[1]。
烟酸（0- 40 μM, 24小时)在低剂量下即可抑制癌细胞的侵袭活性，但对增殖无影响[2]。

体内：烟酸（皮下注射，3-300 mg/kg，一次）可在数分钟内以剂量依赖性方式诱导雄性C57BL/6小鼠血管舒张[3]。

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研究领域：Autophagy  |  Metabolic Enzyme/Protease

作用靶点：Autophagy  |  Endogenous Metabolite

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参考文献：

[1]. Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8.[2]. Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7.[3]. Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18.[4]. Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61.[5]. Wan P, et al. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol. 2011 Jun;164(6):1188-200.[6]. Ishii N, et al. Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):209-15.