中文名:E3连接酶配体1
英文名:(S,R,S)-AHPC-Me hydrochloride
(S,R,S)-AHPC-Me (hydrochloride)
VHL ligand 2 (hydrochloride); E3 ligase Ligand 1
CAS:1948273-03-7
Molecular formula:C23H33ClN4O3S
Molecular weight:481.05
Purity:95%+
Appearance:solid/powder
Matters for use:
It is sensitive to light and temperature. In order to use the reagent effectively, the material should always be kept in a low temperature dry condition, away from light, and avoid frequent thawing and freezing.
storage conditions:
Store at - 20 ℃ as much as possible. If conditions permit, the material can be treated under inert gas to obtain better stability of the reagent.
Packing specification:1g,5g,10g
结构式:
产品介绍:
E3 ligase Ligand 1又称E3连接酶配体1,是用于 PROTAC 技术中的E3连接酶配体。E3连接酶配体1是VHL E3连接酶结合配体。 E3连接酶配体1用于合成ARV-771,一种基于von Hippel-Landau(VHL)E3连接酶的BET PROTAC。 ARV-771是一种基于蛋白水解靶向嵌合体(PROTAC)技术的小分子泛BET降解剂,与BET抑制相比,在去势抵抗性前列腺癌(CRPC)的细胞模型中显示出显着改善的功效。
近年来,随着蛋白质降解技术的不断发展,E3连接酶配体成为了研究的热点之一。而(S,R,S)-AHPC-Me hydrochloride是一种用于PROTAC技术的E3连接酶配体。E3连接酶配体是一种重要的生物化学分子,它在细胞内发挥着至关重要的作用。它能够与E3连接酶结合,从而促进蛋白质降解和细胞代谢的正常进行。在生物体内,E3连接酶配体的稳定性和活性对于细胞的正常功能至关重要。研究表明,E3连接酶配体在细胞周期、细胞凋亡、DNA修复等多个方面发挥着重要作用。
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