Edit and Continue is not supported in 64 bit CLR, however you can use 32
bit CLR on a x64 machine.
As Steve said in his blog:
http://blogs.msdn.com/stevejs/archive/2005/11/15/493018.aspx.
You need to compile your managed assembly with a target CPU of x86. This
will cause the 32 bit CLR to be used rather than the 64 bit CLR.
For a VB Project, right click on the project and go to
Properties/Compile/Advanced Compile Options/Target CPU and set it to "x86".
For a C# Project, right click on the project and go to
Properites/Build/Platform Target and set it to "x86".