Sacituzumab govitecan (IMMU-132) 是一种抗体-药物偶联物 ｜ MedChemExpress (MCE)

Sacituzumab govitecan

CAS：1491917-83-9

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Sacituzumab govitecan (IMMU-132) 是一种抗体-药物偶联物 (ADC)，靶向 Trop-2 以递送 SN-38。 Sacituzumab govitecan 具有抗癌活性[1]。

体内：Sacituzumab govitecan (IMMU-132)（17.5 mg/kg；每周两次，持续 4 周）对携带人胃癌异种移植物的小鼠产生显着的抗肿瘤作用[1]。

参考文献：

[1]. Cardillo TM, et al. Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers. Bioconjug Chem. 2015 May 20;26(5):919-31.
[2]. Goldenberg DM, Cardillo TM, Govindan SV, Rossi EA, Sharkey RM. Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) [published correction appears in Oncotarget. 2020 Mar 10;11(10):942]. Oncotarget. 2015;6(26):22496-22512. 详情:https://www.medchemexpress.cn/sacituzumab-govitecan.html