Caerulomycin A
中文名:浅蓝霉素
CAS:21802-37-9
品牌:MedChemExpress (MCE)
存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
生物活性: Caerulomycin A (Cerulomycin; Caerulomycin) 是一种抗真菌化合物,可诱导 T 细胞的产生,通过抑制干扰素-γ 诱导的 STAT1 信号传导增强 TGF-β-Smad3 蛋白信号传导。抗真菌和抗生素活性,用于自身免疫性疾病[1]。 IC50 和目标:抗真菌
TGF-β-Smad3
参考文献:
[1]. Gurram RK, et al. Caerulomycin A enhances transforming growth factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). J Biol Chem. 2014 Jun 20;289(25):17515-28.