琥珀酸是一种有效的口服活性抗焦虑剂 | MedChemExpress (MCE)

Succinic acid

中文名：琥珀酸

CAS：110-15-6

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：琥珀酸是一种有效的口服活性抗焦虑剂。琥珀酸是三羧酸循环的中间产物。琥珀酸可用作食品、化学和制药工业中许多重要工业化学品的前体[1][2]。 

体外：琥珀酸来源于农业碳水化合物[2]的发酵。

体内：琥珀酸（3, 6 mg/kg；口服）增加雄性小鼠进入张开手臂的百分比和张开手臂的时间[3]。
琥珀酸（3, 6, 12 mg/kg; ip) 给药后 5 分钟和 40 分钟内食物摄入显着增加测量直肠温度，1.5 mg/kg 剂量的琥珀酸抑制应激诱导的体温过高[3 ]。

参考文献：

[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10.
[2]. A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 1948;42(1):ii.
[3]. Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64.
[4]. Xu J, et al. Microbial succinic acid, its polymer poly (butylene succinate), and applications[J]. Plastics from bacteria: Natural functions and applications, 2010: 347-388.
[5]. Bechthold I, et al. Succinic acid: a new platform chemical for biobased polymers from renewable resources[J]. Chemical Engineering & Technology: Industrial Chemistry‐Plant Equipment‐Process Engineering‐Biotechnology, 2008, 31(5): 647-654.