使用 MRI 构建的大脑连接网络预测帕金森病萎缩进展模式| 文献速递-基于深度学习的乳房、前列腺疾病诊断系统

Title

题目

Brain Connectivity Networks Constructed Using  MRI for Predicting Patterns of Atrophy Progression  in Parkinson Disease

使用 MRI 构建的大脑连接网络预测帕金森病萎缩进展模式

Background

背景

Whether connectome mapping of structural and across the brain could be used to predict patterns of atrophy progression in patients with mild Parkinsondisease (PD) has not been well studied.

是否可以使用全脑结构和功能连接的连接组映射来预测轻度帕金森病（PD）患者的萎缩进展模式尚未得到充分研究。

Method

方法

This prospective study included participants with mild PD and controls recruited from a single center between January 2012 and December 2023. Participants with PD underwent three-dimensional T1-weighted brain MRI, and the extent of regional GM atrophy was determined at baseline and every year for 3 years. The structural and functional brain connectome was constructed using diffusion tensor imaging and resting-state functional MRI in healthy controls. Disease exposure (DE) indexes—indexes of the pathology of each brain region—were defined as a function of the structural or functional connectivity of all the connected regions in the healthy connectome and the severity of atrophy of the connected regions in participants with PD. Partial correlations were tested between structural and functional DE indexes of each GM region at 1- or 2-year follow-up and atrophy progression at 2- or 3-year follow-up. Prediction models of atrophy at 2- or 3-year follow-up were constructed using exhaustive feature selection.

这项前瞻性研究包括2012年1月至2023年12月期间从单一中心招募的轻度帕金森病（PD）患者和对照组参与者。PD患者接受了三维T1加权脑MRI扫描，并在基线和每年进行一次灰质（GM）萎缩程度评估，持续3年。健康对照组使用弥散张量成像和静息态功能MRI构建结构和功能脑连接组。疾病暴露（DE）指数——每个脑区病理学的指数——被定义为健康连接组中