be confident of 对...事有信心,确信...(指对某具体的事有信心。如:对学习数学有信心be confident of studying maths)
be confident in 在...方面有信心,在...领域有信心(指在某一个范围,方面有信心。如:在学习方面有信心be confident in study)
be confident with 这个我个人觉得比较泛be confident with studying maths/be confident with study都可以用。