报告 | Seppe Kuehn-微生物群落的结构和功能: 从循环到设计(芝加哥大学)-CSDN博客

报告探讨了微生物群落在环境中的功能，如在碳循环中的作用，以及如何通过社区功能景观预测和设计微生物组合。研究发现，碳循环并不严格依赖特定细菌分类，而代谢功能对生态系统组织有更大影响。此外，提出的社区功能景观概念允许预测集体功能，无需详细物种互动知识，促进了微生物群落的理性设计。

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Structure and function in microbial communities: from cycling to design

报告人

Seppe Kuehn, PhD

Title: Assistant Professor

Institution: University of Chicago

Department : Ecology and Evolution

Websites:

https://profiles.uchicago.edu/profiles/display/20049722

Contact: seppekuehn@uchicago.edu

报告内容

Microbial consortia display intricate functional properties across various environments, such as soils, bioreactors, and human hosts. These properties, ranging from driving biogeochemical cycles to combating pathogens in the gut, are crucial in shaping the biosphere. Understanding how physiology and ecology collaborate within these complex consortia to determine emergent functions poses a central challenge in microbial ecology. This talk presents two studies efforts aimed at addressing this problem.

In the first study, we utilize closed microbial ecosystems (CES) as model biospheres to investigate how communities organize to drive emergent nutrient cycles. A novel technique is developed to quantify carbon cycling in hermetically sealed microbial communities. Our findings demonstrate that CES, composed of an alga and diverse bacterial consortia, autonomously establish robust carbon cycling over extended periods. Interestingly, comparing replicates of diverse CES reveals that carbon cycling is not heavily reliant on the specific bacterial taxonomy present. Despite significant taxonomic differences, self-organized CES consistently exhibit a shared set of metabolic capabilities. Thus, the emergent carbon cycle imposes metabolic, but not taxonomic, constraints on ecosystem organization.

In the second study, we introduce the concept of community-function landscapes, analogous to fitness landscapes, which capture how alterations in community composition affect collective function. Leveraging datasets representing diverse community functions, we demonstrate that statistically-inferred landscapes accurately predict community functions based on the presence or absence of specific strains. Crucially, community-function landscapes enable prediction without explicit knowledge of abundance dynamics or species interactions. The success of our approach arises from the observation that empirical community-function landscapes tend to not be rugged. This breakthrough facilitates the rational design of consortia without requiring detailed knowledge of abundance dynamics or species interactions.

报告时间和网址

报告时间：August 2nd, 10am (Boston time)

报告网址：https://mit.zoom.us/j/98064791031

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“iMeta” 是由威立、肠菌分会和本领域数百位华人科学家合作出版的开放获取期刊，主编由中科院微生物所刘双江研究员和荷兰格罗宁根大学傅静远教授担任。目的是发表原创研究、方法和综述以促进宏基因组学、微生物组和生物信息学发展。目标是发表前10%(IF > 15)的高影响力论文。期刊特色包括视频投稿、可重复分析、图片打磨、青年编委、前3年免出版费、50万用户的社交媒体宣传等。2022年2月正式创刊发行！

联系我们

iMeta主页：http://www.imeta.science

出版社：https://onlinelibrary.wiley.com/journal/2770596x
投稿：https://mc.manuscriptcentral.com/imeta
邮箱：office@imeta.science