回顾: 在Rosetta中计算氨基酸突变影响的方法

作者: 刘源

简介: 北京大学化学与分子工程学院-王初题组特聘博士后

参考1: Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
参考2: The Rosetta all-atom energy function for macromolecular modeling and design
参考3: Simultaneous optimization of biomolecular energy function on features from small molecules and macromolecules
参考4: Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.
参考5:  https://www.rosettacommons.org/demos/latest/tutorials/Optimizing_Sidechains_The_Packer/Optimizing_Sidechains_The_Packer

一、前言

计算蛋白突变体的能量是Rosetta最