AbMole| Guselkumab 古塞库/古塞奇尤单抗(CAS号： 1350289-85-8)

Guselkumab（古塞奇尤单抗）是一种重组人源性 IgG1 单克隆抗体，针对 IL-23p19 亚基，能抑制 IL-23 信号通路下游细胞因子的产生，与人和食蟹猴 IL-23 的结合值 Kd 分别为 3.3 pM 和 1.9 pM，可用于银屑病关节炎，类风湿关节炎以及炎症性肠病（IBD）的相关研究。

化学性质

CAS号	1350289-85-8
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参考文献

[1] No authors listed. Guselkumab

[2] William J Sandborn, et al. Gastroenterology. Guselkumab for the Treatment of Crohn's Disease: Induction Results From the Phase 2 GALAXI-1 Study

[3] Atul Deodhar, et al. Lancet. Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFα inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial