Doxycycline hydrochloride 是一种抗生素 |MedChemExpress (MCE)

中文名：盐酸多西环素

CAS：10592-13-9

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Doxycycline hydrochloride 是一种抗生素，是一种具有口服活性的广谱金属蛋白酶 (MMP) 抑制剂[1]。盐酸多西环素具有抗菌活性和抗癌细胞增殖活性[1][2][3][4][5]。 

体外：Doxycycline hydrochloride (0.01-10 µg/mL, 4 d) 仅在高浓度下影响胶质瘤细胞的生长[2]。
Doxycycline hydrochloride (0.01-10 µg/mL, 24 h)在 SVG 细胞中浓度为 1 µg/mL 或更高时降低 MT-CO1 蛋白含量[2]。
盐酸多西环素（100 ng/mL，1 µg/mL；24 小时）降低人类细胞系的增殖[4].
Doxycycline hydrochloride (0-250 μM, 72 h) 抑制乳腺癌细胞的细胞活力[5].< br/>

体内：Doxycycline hydrochloride（口服灌胃；200 或 800 mg/kg；每日一次；3 个月）以剂量依赖性方式降低未治疗 HT 小鼠的 MMP-9 活性[3]。

 参考详情：https://www.medchemexpress.com/doxycycline-hydrochloride.html

参考文献：

[1]. Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7.

[2]. Eusebio Manchado, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016 Jun 30;534(7609):647-51.

[3]. Anna-Luisa Luger, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504

[4]. Ethan Ahler, et al. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013 May 31;8(5):e64561.

[5]. Le Zhang, et al. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017 Apr 18;16(8):737-745.