Desloratadine (Sch34117) 是具有口服活性的非镇静剂 H1-抗组胺药 Loratadine 的主要代谢物 |MedChemExpress (MCE)

中文名：地氯雷他定

CAS：100643-71-8

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Desloratadine (Sch34117) 是具有口服活性的非镇静剂 H1-抗组胺药 Loratadine 的主要代谢物。 Desloratadine 是一种选择性 H1 受体 拮抗剂，具有抗过敏和抗炎作用[1][2]。

 参考详情：https://www.medchemexpress.com/Desloratadine.html

参考文献：

[1]. Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107(4): p. 751-62.

[2]. Schroeder, J.T., et al., Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin Exp Allergy, 2001. 31(9): p. 1369-77.

[3]. Anthes, J.C., et al., Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol, 2002. 449(3): p. 229-37.

[4]. McClellan K, et al. Desloratadine. Drugs. 2001;61(6):789-797.