核黄素是一种易于吸收的微量营养素 | MedChemExpress (MCE)

参考详情：https://www.medchemexpress.com/riboflavin.html

中文名：维生素 B2

CAS：83-88-5

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light

生物活性：核黄素是一种易于吸收的微量营养素，在维持人类和其他动物的健康方面发挥着关键作用。目标：其他 核黄素（维生素 B2）是氧化还原酶辅助因子黄素单核苷酸 (FMN) 和黄素腺嘌呤二核苷酸 (FAD) 的直接前体，它们对多细胞生理学至关重要 [1]。核黄素的尿液排泄占血浆中核黄素总去除量的一半。对于任何药代动力学变量均未观察到性别差异 (P > 0.05) [2]。与 B 复合物的其他维生素类似，核黄素具有抗炎活性，但尚未对其进行全面表征。核黄素（25、50 或 100 mg/kg，腹腔注射）在注射角叉菜胶后立即和 2 小时给药，可诱导抗水肿和镇痛作用。用黄素激酶抑制剂硫酸镉 (1 mg/kg) 预处理不会抑制镇痛作用。核黄素（50 或 100 毫克/千克，腹腔注射，0 小时和 2 小时）也抑制大鼠由脂多糖 (LPS) 引起的发热。核黄素是一种安全的药物，已获准用于临床并可增强吗啡的镇痛作用，可能需要进行临床试验以评估其治疗不同疼痛或炎症状况的潜力 [3]。

体外：Riboflavin (5-50 µM, 24 h) 在紫外光照射后对 HL60 细胞具有很强的细胞毒作用，这是由细胞凋亡介导的[2]。 Riboflavin (0.76-48.76 nM, 96 h) 以剂量依赖性方式提高HepG2 细胞的活力和谷胱甘肽还原酶活性，并减少细胞凋亡[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Riboflavin (10 mg/kg, 口服, 每日一次) 促进 swiss albino 小鼠的生长[4]。 Riboflavin (1-600 mg/kg, 口服, 一次) 在福尔马林、卡拉胶诱导的热痛觉过敏和脊髓神经结扎大鼠模型中具有抗痛觉、抗过敏和抗炎作用[5]。 Riboflavin (3-100 mg/kg，腹腔注射，一次) 在乙酸诱导的收缩小鼠模型中以剂量依赖性方式抑制伤害性反应[6]。 Riboflavin (6-12 mg/kg，腹腔注射，一次) 可降低甲醛诱导的小鼠模型的第二阶段伤害性反应[6]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Swiss albino mice[4] Dosage: 10 mg/kg Administration: Oral gavage (p.o.), daily Result: Increased the growth rate of pregnant and newbron mice. Increased the percent conception and average litter size of pregnant mices. Improved the percent zinc absorption in male mices. Increased the levels of zinc and iron in organs in male and female mices. Increased the percent hemoglobin and the blood zinc value of female mices. Animal Model: Female Wistar rats[5] Dosage: 1-600 mg/kg Administration: Oral gavage (p.o.), one time Result: Reduced flinching behavior during phase 2 in formalin-injected mice by doses of 1-50 mg/kg. Produced a significant antihyperalgesic effect in carrageenan-injected mice by doses of 6.25-150 mg/kg. Reduced carrageenan-induced edema by doses of 50-150 mg/kg. Didn’t reduce tactile allodynia in the spinal nerve ligation model by doses of 150-600 mg/kg. Clinical Trial

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参考文献：

[1]. Thakur K, et al. Riboflavin and health: A review of recent human research. Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3650-3660.

[2]. de Souza AC, et al. A promising action of riboflavin as a mediator of leukaemia cell death. Apoptosis. 2006 Oct;11(10):1761-71.

[3]. Xin Z, et al. Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells. Sci Rep. 2017 Apr 3;7:45861.

[4]. Agte VV, et al. Effect of riboflavin supplementation on zinc and iron absorption and growth performance in mice. Biol Trace Elem Res. 1998 Nov;65(2):109-15.

[5]. Granados-Soto V, et al. Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat. Eur J Pharmacol. 2004 May 10;492(1):35-40.

[6]. França DS, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001 Jun 15;421(3):157-64.