The importance of long non-coding RNAs in neuropsychiatric disorders（ 长链非编码RNAs在神经精神疾病中的重要性）

In the last decade, transcriptome analyses have discovered thousands of long non-coding RNAs (lncRNAs) which are assumed as a fundamental part of the gene regulatory networks in the cell. Intriguingly, lncRNAs are abundantly enriched in the brain, displaying elaborate spatiotemporal expression profiles and modulation. They diversely participate in the delicate regulation of the central nervous system (CNS) development including self-renewal maintenance, cell fate decision, synapse plasticity, synaptogenesis and memory formation. Moreover, lncRNAs have vastly demonstrated correlations with mental illnesses such as neuropsychiatric disorders (NPDs), implying the vital jobs of these yet poorly-understood transcripts. Here, we underlie the accumulating evidence for the significance of lncRNAs in neural networks and their impairment in several NPDs including autism spectrum disorder (ASD), schizophrenia (SZ), intellectual disability (ID), major depressive disorder(MDD), Rett syndrome (RTT) and others.

在过去十年，转录组学分析已经发现成千上万个长链非编码RNAs，它们被认为是细胞基因调控网络的基本组成部分。有趣的是，大脑中富含lncRNAs，呈现出精细的时空表达谱和调节。它们不同程度地参与中枢神经系统(CNS)发育的微妙调节，包括自我更新维持，细胞生命决定，突触可塑性，突触发生和记忆形成。此外，lncRNAs已被广泛证明与神经精神疾病(NPDs)等精神疾病相关，这意味着这些尚未被充分理解的转录本的重要作用。在此，我们为lncRNA在神经网络中的重要性及其在包括自闭症谱系障碍(ASD)、精神分裂症(SZ)、智力障碍(ID)、重度抑郁症(MDD)、Rett综合征(RTT)等几种神经精神疾病（NPDs）中的损伤提供了越来越多的证据。

2019 Jul 15 发表于Mol Aspects Med（IF8.313）