根据pubmed给我推送的前20条 IF>10 “Proteomics” 相关文献记录,我将它们按照*“期刊-题目-主要内容”*格式整理,并分为大数据、机制研究和其他三类:
大数据
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Nat Commun
- Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer
主要内容:利用CRISPR/Cas9筛选系统研究了三阴性乳腺癌(TNBC)中NEDD8缺失对免疫检查点阻断疗法的影响。
- Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer
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Nat Commun
- An individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma
主要内容:提出了一种基于机器学习的方法,通过评估临床因素和蛋白质组来预测儿童乳头状甲状腺癌的复发风险。
- An individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma
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Nat Commun
- Metabolomics facilitates differential diagnosis in common inherited retinal degenerations by exploring their profiles of serum metabolites
主要内容:利用代谢组学特征和机器学习模型,提出了一种基于代谢物热图的诊断工作流程,用于临床和分子诊断遗传性视网膜退行性疾病。
- Metabolomics facilitates differential diagnosis in common inherited retinal degenerations by exploring their profiles of serum metabolites
机制研究
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Allergy
- Neutrophil-driven and interleukin-36γ-associated ocular surface inflammation in chronic Stevens-Johnson syndrome
主要内容:研究了慢性Stevens-Johnson综合征/中毒性表皮坏死松解型(SJS/TEN)患者的泪液蛋白质组,以及与SJS/TEN后眼部并发症相关的分子机制。
- Neutrophil-driven and interleukin-36γ-associated ocular surface inflammation in chronic Stevens-Johnson syndrome
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Acta Biomater.
- Deciphering protein-mediated underwater adhesion in an invasive biofouling ascidian: discovery, validation, and functional mechanism of an interfacial protein
主要内容:通过定量蛋白质组学评估了模型污损海鞘Ciona robusta中粘合结构的蛋白表达变化,发现了新的粘合蛋白,并探讨了其在水下粘合中的作用。
- Deciphering protein-mediated underwater adhesion in an invasive biofouling ascidian: discovery, validation, and functional mechanism of an interfacial protein
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J Hepatol.
- Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
主要内容:研究了核仁蛋白(Nucleolin)乳酸化在肝内胆管癌(iCCA)发病机制中的作用,特别是通过RNA剪接调节MADD蛋白。
- Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
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Nat Commun
- The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms
主要内容:使用定量蛋白质组学方法鉴定了胰腺癌中癌症干细胞(CSCs)的分泌蛋白,并探讨了E2F1/4-pRb/RBL2轴如何调节CSCs的特性。
- The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms
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Nat Commun
- HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription
主要内容:研究表明HBO1作为赖氨酸乳酸化转移酶,通过调节组蛋白H3K9la来调控基因转录。
- HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription
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Cardiovasc Res.
- Serine protease inhibitor, SerpinA3n regulates cardiac remodeling after myocardial infarction
主要内容:研究了在心肌梗死后心脏重塑中调节基质蛋白酶活性的丝氨酸蛋白酶抑制剂SerpinA3n的作用。
- Serine protease inhibitor, SerpinA3n regulates cardiac remodeling after myocardial infarction
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J Nanobiotechnology
- Young osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1
主要内容:研究了年轻成骨细胞来源的细胞外囊泡(YO-EVs)如何通过转移肌动蛋白-1(tropomyosin-1)来促进成骨作用。
- Young osteocyte-derived extracellular vesicles facilitate osteogenesis by transferring tropomyosin-1
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Nat Commun
- Numb positively regulates Hedgehog signaling at the ciliary pocket
主要内容:使用邻近标记和定量蛋白质组学,确定了Numb作为调节Hh信号的细胞器蛋白。
- Numb positively regulates Hedgehog signaling at the ciliary pocket
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Cardiovasc Res.
- Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction
主要内容:使用蛋白质组学分析了心力衰竭和窦房结功能障碍(SND)小鼠模型中窦房结的蛋白质和磷酸化重塑。
- Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction
其他
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J Hepatol.
- Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
主要内容:探讨了代谢重编程和典型肿瘤起始事件之间的新联系,并提供了可用于临床iCCA预后评估和靶向治疗的生物标志物。
- Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD
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Annu Rev Biochem
- Reading and Writing the Human Glycocode
主要内容:综述了糖基转移酶(形成糖组的“写入者”)和糖结合蛋白(在解码糖功能中起重要作用的“阅读者”)。
- Reading and Writing the Human Glycocode
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Sci Adv
- An osteoarthritis pathophysiological continuum revealed by molecular biomarkers
主要内容:旨在鉴定膝关节骨关节炎(OA)的血清生物标志物,这些标志物能在放射学异常出现之前预测OA的发生。
- An osteoarthritis pathophysiological continuum revealed by molecular biomarkers
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Nat Chem Biol
- Pyro(phospho)mania
主要内容:文献摘要不可用。
- Pyro(phospho)mania
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J Allergy Clin Immunol
- Distinct proteomes and allergen profiles appear across the life cycle stages of Alternaria alternata
主要内容:定量比较了不同生命周期阶段的Alternaria alternata的蛋白质组,发现孢子和菌丝表达重叠但不同的蛋白质组。
- Distinct proteomes and allergen profiles appear across the life cycle stages of Alternaria alternata
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Science
- Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
主要内容:报道了小分子片段与蛋白质结合倾向的蛋白质组范围图,有助于加速迄今为止未被药物靶向的蛋白质的配体发现工作。
- Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
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Circ Res
- Proteomics, Human Environmental Exposure, and Cardiometabolic Risk
主要内容:测试了循环蛋白质与多种环境暴露的关系,并评估了环境组学特征与心血管疾病和死亡率的关系。
- Proteomics, Human Environmental Exposure, and Cardiometabolic Risk