DNA sequencing technologies: 2006–2016

DNA sequencing technologies: 2006–2016

• Elaine R Mardis 

Nature Protocols volume 12, pages213–218(2017)Cite this article

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Abstract

Recent advances in the field of genomics have largely been due to the ability to sequence DNA at increasing throughput and decreasing cost. DNA sequencing was first introduced in 1977,

and next-generation sequencing technologies have been available only during the past decade,

but the diverse experiments and corresponding analyses facilitated by these techniques have transformed biological and biomedical research.

Here, I review developments in DNA sequencing technologies over the past 10 years and look to the future for further applications.

最近在基因组学领域的进展很大程度上是由于DNA序列的能力，以增加通量和降低成本。
DNA测序于1977年首次推出，下一代测序技术是在过去十年才出现的，
但这些技术促成的各种实验和相应分析已经改变了生物学和生物医学研究。
在此，我回顾了过去10年来DNA测序技术的发展，并展望了未来进一步的应用。