细胞亚器互作之细胞代谢调节液泡与线粒体的接触位Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria

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最新推荐文章于 2024-09-03 01:25:46 发布

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研究揭示细胞代谢状态通过调节Vps39磷酸化影响线粒体与液泡间的接触位点（vCLAMPs），这种接触与内吞途径和ER-线粒体接触位点（ERMES）相互作用，参与细胞生理和代谢物质交换。vCLAMPs的动态变化可能由代谢调控激酶如TOR、Snf1/AMPK和PKA控制，为理解细胞内膜接触位点的生理功能提供了新的视角。

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细胞亚器互作之细胞代谢调节液泡与线粒体的接触位(Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria）

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这篇文章与往期的文章不同的是，这篇文章作者发现在线粒体和溶酶体样的囊泡的膜表面存在这一种与GTPase相关的复合体膜接触位点(vCLAMP (vacuole and mitochondria patch) that integrates mitochondria with the lysosome-like vacuole and thus the endocytic pathway.)并且这种膜接触位点能够整合内吞途径，作者发现(vCLAMPs depend
on the vacuolar HOPS tethering complex subunit Vps39/Vam6 and the Rab GTPase Ypt7, which also
participate in membrane fusion at the vacuole. Intriguingly, vCLAMPs are located proximal to the ER-mitochondria encounter structure (ERMES) complexes, and an increase in vCLAMPs can rescue the growth defect of ERMES mutants. Importantly, the persistence of vCLAMPs is regulated by phosphorylation of Vps39 and is stro