基于TCGA肿瘤数据进行基因共表达网络分析
WGCNA概述
WGCNA
(Weighted Gene Coexpression Network Analysis)是一个基于基因表达数据构建基因共表达网络的方法。WGCNA
和差异基因分析
的区别在于:
差异基因分析
主要针对样本
之间的差异,WGCNA
主要针对基因
之间的关系。
WGCNA原文
WGCNA begins with the understanding that the information captured by microarray experiments is far richer than a list of
differentially expressed genes. Rather, microarray data are more completely represented by considering the relationships
between measured transcripts, which can be assessed by pair-wise correlations between gene expression profiles.
In most microarray data analyses, however