MachineLearning 24. 机器学习之似然增强Cox 比例风险模型筛选变量及预后估计 (CoxBoost)...

于 2024-02-28 12:13:28 发布
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简     介

CoxBoost使用基于组件似然的增强来拟合Cox比例风险模型。特别适用于具有大量预测器的模型，并允许具有无惩罚参数估计的强制协变量。

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与梯度增强(例如在R包mboost中的glmboost例程中实现，使用CoxPH损失函数)相比，CoxBoost不是基于损失函数的梯度，而是采用Tutz和Binder(2007)的基于偏移量的增强方法来估计Cox比例风险模型。在每个增强步骤中，将前面的增强步骤作为惩罚的部分似然估计的偏移量，用于在每个增强步骤中获得单个参数的更新，即一个协变量。这导致稀疏拟合类似于类似lasso的方法，其中许多估计系数为零。必须选择的主要模型复杂性参数(例如，通过使用cv.CoxBoost进行交叉验证)是提升步骤数stepno。惩罚参数惩罚可以相当粗略地选择，可以手工选择，也可以使用optimCoxBoostPenalty。与梯度增强相比，基于偏移量的方法的优点是惩罚结构非常灵活。在目前的实现中，这用于允许无惩罚的强制协变量，在增强步骤的过程中获得非常快的系数积累，而其他(可选)协变量则受到惩罚。例如，在微阵列设置中，(许多)微阵列特征将被视为可选协变量，而(少数)潜在临床协变量将被视为强制性协变量，通过将其索引包含在unpen.index中。如果一组相关协变量对反应有影响，例如，来自同一途径的基因，则分量增强通常会导致该组中只有一个成员的非零估计。为了避免这种情况，有关协变量之间的联系的信息可以在垂直分布中提供。如果这样，另外，一个惩罚更新方案与步长。因素< 1; 如果在之前的增强步骤中选择了直接关联的协变量，则在未来的增强步骤中更有可能选择关联的协变量(参见Binder和Schumacher, 2009b)。

软件包安装

library(devtools)
install_github("binderh/CoxBoost")

数据读取

读取数据

数据我们依然使用TCGA-LUSC的表达数据和临床数据，合并整理之后的结果。然后去掉一些缺失，其他基本对数据进行预处理都有分享过，这里就直接使用，以免增加过多的代码。

lung <- read.table("TCGA_LUSC.m6A_gene.exp_clin.txt", header = T)
table(lung$status)
## 
##   1   2 
## 343 158
lung$status <- ifelse(lung$status == 2, 1, 0)
lung <- na.omit(lung)  # 去掉NA
head(lung)
##   Tumor_Sample_Barcode gender vital_status status time    YTHDC2   IGF2BP2
## 1         TCGA-18-3406   MALE         Dead      1  371 10.490851  8.870365
## 2         TCGA-18-3407   MALE         Dead      1  136 11.032735  8.603626
## 3         TCGA-18-3408 FEMALE        Alive      0 2099  9.796040 11.279611
## 4         TCGA-18-3409   MALE        Alive      0 2417  9.856426 12.023061
## 5         TCGA-18-3410   MALE         Dead      1  146 11.074810  6.584963
## 6         TCGA-18-3411 FEMALE        Alive      0 1415  9.881114 12.384514
##     YTHDC1   ALKBH5   HNRNPC     FMR1 HNRNPA2B1   ZC3H13   IGF2BP3      FTO
## 1 10.69870 10.68738 14.38485 10.59059  13.69675 10.23122  6.523562 10.58684
## 2 12.28511 11.84823 14.44876 11.49935  15.05431 11.94361  9.579316 11.26268
## 3 11.57128 12.10165 14.67325 11.72877  14.47168 11.24911 10.005625 11.33204
## 4 11.92258 12.32839 14.16034 11.19168  14.44320 11.83368  4.954196 11.58825
## 5 11.98762 12.39714 14.92435 11.17555  15.51209 11.36632  9.786270 10.91289
## 6 11.56701 12.23751 15.74026 10.48784  15.16632 10.94910 10.558421 11.18177
##     METTL14     WTAP   YTHDF1   IGF2BP1    RBM15 KIAA1429    METTL3   YTHDF3
## 1  9.063395 13.19583 10.61102  2.584963 8.164907 10.85720  8.924813 12.03032
## 2  9.552669 12.67331 12.07046  1.584963 9.087463 11.58543 10.689124 12.26004
## 3  9.949827 12.61218 11.92518  2.584963 8.280771 11.45224 10.134426 12.23182
## 4 10.675957 12.28135 11.25798  2.321928 9.038919 12.19476 10.029287 12.48734
## 5 10.990104 14.66217 11.67375  7.643856 9.594325 12.09902 10.813781 12.80272
## 6  9.914385 12.97549 11.51668 11.499348 9.204571 12.02721 11.310613 12.48382
##     YTHDF2
## 1 11.31175
## 2 12.31175
## 3 11.53916
## 4 12.17773
## 5 12.20427
## 6 11.96939

数据分割

######## 数据分割
library(sampling)
set.seed(123)
# 每层抽取70%的数据
train_id <- strata(lung, "status", size = rev(round(table(lung$status) * 0.7)))$ID_unit
# 训练数据
trainData <- lung[train_id, ]
# 测试数据
testData <- lung[-train_id, ]

实例操作

1. 构建模型

CoxBoost函数使用如下，可以看到除了随访时间和结局外，还有stepno 和 penalty两个参数需要确认，并且后续需要经过优化后的参数构建最优模型。

train.x <- as.matrix(trainData[, 6:24])
library(CoxBoost)
set.seed(129)
cbfit <- CoxBoost(time = trainData$time, status = trainData$status, x = train.x,
    stepno = 100, penalty = 100)
summary(cbfit)
## 100 boosting steps resulting in 18 non-zero coefficients  
## partial log-likelihood: -485.4118 
## 
## parameter estimates > 0:
##  HNRNPA2B1, ZC3H13, FTO, YTHDF1, KIAA1429, YTHDF3, YTHDF2 
## parameter estimates < 0:
##  IGF2BP2, YTHDC1, ALKBH5, HNRNPC, FMR1, IGF2BP3, METTL14, WTAP, IGF2BP1, RBM15, METTL3
plot(cbfit)

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2. 交叉验证

########### 交叉验证 10-fold cross-validation
cv.res <- cv.CoxBoost(time = trainData$time, status = trainData$status, x = train.x,
    maxstepno = 500, K = 10, type = "verweij", penalty = 100)

# # examine mean partial log-likelihood in the course of the boosting steps
plot(cv.res$mean.logplik)

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3. 优化参数penalty和stepno

最优stepno可以从交叉模型中获取，而使用optimCoxBoostPenalty函数筛选当前数据的最优penalty ，将得到的pen$penalty 定为最终模型的参数：

### 
cv.res$optimal.step
## [1] 3
pen <- optimCoxBoostPenalty(trainData$time,
                            trainData$status,
                            train.x,
                            trace=TRUE,
                            #start.penalty=500,
                            parallel = T)
## iteration 1 : evaluating penalty 972 
## cv fold 1: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP1 METTL3 KIAA1429 FMR1 ZC3H13 IGF2BP3 KIAA1429 FMR1 KIAA1429 FMR1 ZC3H13 METTL3 KIAA1429 FMR1 IGF2BP1 HNRNPA2B1 FMR1 ZC3H13 METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 HNRNPC IGF2BP1 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 FMR1 YTHDC2 IGF2BP3 METTL3 HNRNPA2B1 FMR1 KIAA1429 HNRNPC HNRNPA2B1 IGF2BP1 FMR1 HNRNPA2B1 METTL3 KIAA1429 WTAP HNRNPA2B1 FMR1 IGF2BP2 HNRNPA2B1 HNRNPC KIAA1429 METTL3 HNRNPA2B1 FMR1 YTHDF1 IGF2BP3 IGF2BP1 HNRNPA2B1 FMR1 KIAA1429 HNRNPC YTHDF1 FMR1 HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 FMR1 KIAA1429 WTAP YTHDF1 HNRNPC HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 FMR1 YTHDF1 FMR1 YTHDC2 METTL3 HNRNPA2B1 IGF2BP1 WTAP KIAA1429 FMR1 YTHDF1 HNRNPC HNRNPA2B1 FMR1 KIAA1429 IGF2BP2 METTL3 HNRNPA2B1 FMR1 YTHDF1 HNRNPC HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 YTHDF1 WTAP IGF2BP1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 IGF2BP2 KIAA1429 HNRNPC YTHDF1 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 YTHDC2 WTAP YTHDF1 FMR1 IGF2BP2 KIAA1429 METTL14 YTHDF1 HNRNPC HNRNPA2B1 METTL3 IGF2BP1 HNRNPA2B1 METTL14 KIAA1429 HNRNPC YTHDF1 METTL14 KIAA1429 FMR1 HNRNPA2B1 IGF2BP2 METTL3 HNRNPA2B1 METTL14 YTHDF1 IGF2BP1 FMR1 YTHDC2 METTL14 YTHDF1 IGF2BP3 KIAA1429 ALKBH5 HNRNPA2B1 METTL14 YTHDF1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 METTL14 YTHDF1 ALKBH5 IGF2BP1 KIAA1429 METTL14 YTHDF1 HNRNPC HNRNPA2B1 
## cv fold 2: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 WTAP KIAA1429 WTAP METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 WTAP METTL3 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 WTAP HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 WTAP FTO FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 WTAP YTHDF2 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 WTAP YTHDF2 FMR1 HNRNPA2B1 METTL3 YTHDF2 WTAP FTO FMR1 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 IGF2BP3 WTAP HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 METTL3 YTHDF2 WTAP IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 METTL3 YTHDF2 HNRNPC HNRNPA2B1 FMR1 YTHDF2 WTAP HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 YTHDF2 HNRNPC HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 WTAP HNRNPC YTHDF2 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP2 HNRNPA2B1 HNRNPC FMR1 YTHDF2 WTAP HNRNPA2B1 METTL3 FTO FMR1 HNRNPA2B1 IGF2BP3 YTHDF2 METTL14 HNRNPA2B1 HNRNPC METTL3 HNRNPA2B1 IGF2BP2 FMR1 YTHDF2 METTL14 KIAA1429 WTAP HNRNPA2B1 METTL3 YTHDF2 HNRNPC HNRNPA2B1 METTL14 FTO FMR1 YTHDF2 METTL14 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 HNRNPC YTHDF2 METTL14 KIAA1429 FMR1 HNRNPA2B1 HNRNPC YTHDF2 METTL14 FTO WTAP HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 METTL14 YTHDF2 FMR1 KIAA1429 IGF2BP3 METTL14 HNRNPA2B1 METTL3 YTHDF2 HNRNPC HNRNPA2B1 METTL14 FTO FMR1 HNRNPA2B1 WTAP YTHDF2 
## cv fold 3: KIAA1429 KIAA1429 FTO KIAA1429 KIAA1429 FTO METTL3 KIAA1429 IGF2BP1 METTL3 KIAA1429 IGF2BP1 KIAA1429 METTL3 ZC3H13 METTL3 KIAA1429 IGF2BP1 METTL3 KIAA1429 IGF2BP1 METTL3 KIAA1429 ZC3H13 METTL3 KIAA1429 IGF2BP1 METTL3 ZC3H13 WTAP KIAA1429 METTL3 KIAA1429 WTAP IGF2BP1 KIAA1429 FMR1 ZC3H13 FMR1 KIAA1429 WTAP ZC3H13 METTL3 IGF2BP1 KIAA1429 FMR1 HNRNPA2B1 WTAP KIAA1429 FMR1 ZC3H13 METTL3 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 WTAP KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP1 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 WTAP IGF2BP1 HNRNPA2B1 METTL3 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 WTAP KIAA1429 FMR1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 ZC3H13 METTL3 HNRNPA2B1 IGF2BP1 FMR1 KIAA1429 WTAP HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 HNRNPC IGF2BP1 HNRNPA2B1 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 WTAP KIAA1429 HNRNPC HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 HNRNPC KIAA1429 METTL3 HNRNPA2B1 FMR1 IGF2BP1 HNRNPA2B1 HNRNPC KIAA1429 WTAP HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 METTL14 YTHDF2 FMR1 KIAA1429 METTL14 HNRNPA2B1 HNRNPC YTHDF2 FMR1 FTO METTL14 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 METTL14 YTHDF2 HNRNPC YTHDF1 WTAP KIAA1429 METTL14 YTHDF2 FMR1 HNRNPA2B1 METTL3 IGF2BP1 HNRNPA2B1 HNRNPC YTHDF1 METTL14 YTHDF2 FMR1 KIAA1429 HNRNPC HNRNPA2B1 METTL14 IGF2BP3 YTHDF2 METTL14 YTHDF1 METTL3 HNRNPA2B1 
## cv fold 4: FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 YTHDC2 HNRNPC HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 HNRNPC KIAA1429 HNRNPC HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 METTL3 KIAA1429 WTAP HNRNPA2B1 HNRNPC HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 WTAP HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 HNRNPC KIAA1429 IGF2BP1 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 HNRNPC KIAA1429 IGF2BP3 METTL3 HNRNPA2B1 WTAP HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 HNRNPC KIAA1429 METTL3 HNRNPA2B1 IGF2BP1 WTAP HNRNPA2B1 METTL3 KIAA1429 HNRNPC HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP1 HNRNPC HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 WTAP HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 IGF2BP1 KIAA1429 HNRNPC YTHDF1 FMR1 HNRNPA2B1 HNRNPC YTHDF1 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 WTAP KIAA1429 FMR1 YTHDF1 IGF2BP1 HNRNPC HNRNPA2B1 YTHDC1 KIAA1429 METTL3 HNRNPA2B1 YTHDC1 YTHDF1 HNRNPC HNRNPA2B1 FMR1 IGF2BP1 HNRNPA2B1 YTHDC1 YTHDF1 YTHDC1 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 HNRNPC HNRNPA2B1 YTHDC1 HNRNPA2B1 YTHDC1 YTHDF1 IGF2BP1 FMR1 HNRNPA2B1 YTHDC1 YTHDF1 HNRNPC KIAA1429 YTHDC1 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 YTHDC1 HNRNPA2B1 IGF2BP1 YTHDF1 YTHDC1 YTHDC2 FMR1 HNRNPA2B1 HNRNPC KIAA1429 YTHDC1 YTHDF1 METTL3 HNRNPA2B1 YTHDC1 IGF2BP1 HNRNPA2B1 HNRNPC YTHDF1 YTHDC1 HNRNPA2B1 FMR1 KIAA1429 YTHDC1 YTHDC2 IGF2BP3 METTL3 HNRNPA2B1 YTHDC1 YTHDF1 HNRNPC HNRNPA2B1 YTHDC1 YTHDF3 IGF2BP1 
## cv fold 5: FTO FTO KIAA1429 KIAA1429 FTO KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 FTO IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 FMR1 KIAA1429 IGF2BP3 KIAA1429 FMR1 KIAA1429 FMR1 IGF2BP3 KIAA1429 FMR1 FTO IGF2BP2 KIAA1429 FMR1 KIAA1429 FMR1 IGF2BP2 KIAA1429 FMR1 FTO IGF2BP3 KIAA1429 FMR1 KIAA1429 FMR1 IGF2BP2 KIAA1429 FMR1 KIAA1429 METTL3 FTO WTAP IGF2BP2 KIAA1429 FMR1 YTHDF2 WTAP KIAA1429 FMR1 YTHDF2 WTAP FTO FMR1 YTHDF2 WTAP YTHDF2 FMR1 KIAA1429 WTAP YTHDF2 METTL3 IGF2BP2 KIAA1429 FMR1 YTHDF2 WTAP YTHDF2 FMR1 FTO WTAP YTHDF2 WTAP KIAA1429 FMR1 YTHDF2 IGF2BP3 METTL3 KIAA1429 WTAP YTHDF2 FMR1 YTHDF2 WTAP KIAA1429 FMR1 YTHDF2 WTAP IGF2BP2 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 WTAP FTO FMR1 YTHDF2 WTAP HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 IGF2BP2 FMR1 KIAA1429 WTAP HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 YTHDF2 WTAP HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 IGF2BP2 WTAP KIAA1429 FMR1 HNRNPA2B1 METTL3 YTHDF2 ALKBH5 FTO WTAP YTHDF1 FMR1 HNRNPA2B1 IGF2BP2 ALKBH5 YTHDF2 FMR1 HNRNPA2B1 IGF2BP1 ALKBH5 YTHDF1 METTL3 KIAA1429 WTAP YTHDF2 ALKBH5 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 ALKBH5 YTHDF2 METTL3 YTHDF1 WTAP FTO FMR1 HNRNPA2B1 ALKBH5 YTHDF2 FMR1 YTHDF2 WTAP HNRNPA2B1 ALKBH5 IGF2BP1 KIAA1429 IGF2BP2 YTHDF1 ALKBH5 FMR1 HNRNPA2B1 METTL3 YTHDF2 WTAP FTO ALKBH5 HNRNPA2B1 FMR1 YTHDF2 IGF2BP3 YTHDF1 ALKBH5 KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP1 HNRNPA2B1 ALKBH5 YTHDF2 
## cv fold 6: FTO KIAA1429 FTO KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 FTO METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 WTAP IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 IGF2BP2 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 FMR1 KIAA1429 IGF2BP2 METTL3 HNRNPA2B1 WTAP FTO FMR1 HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 FMR1 KIAA1429 WTAP HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 IGF2BP2 METTL3 HNRNPA2B1 FMR1 FTO WTAP HNRNPA2B1 METTL3 IGF2BP2 KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 YTHDF2 WTAP HNRNPA2B1 METTL3 FTO FMR1 HNRNPA2B1 IGF2BP2 FMR1 YTHDF2 WTAP KIAA1429 METTL3 HNRNPA2B1 FMR1 YTHDF2 WTAP HNRNPA2B1 FMR1 IGF2BP2 YTHDF2 METTL3 HNRNPA2B1 WTAP FTO FMR1 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 WTAP IGF2BP2 YTHDF2 METTL3 HNRNPA2B1 FMR1 KIAA1429 WTAP IGF2BP3 HNRNPA2B1 FMR1 YTHDF2 METTL3 HNRNPA2B1 METTL14 YTHDF2 FMR1 FTO WTAP HNRNPA2B1 METTL14 YTHDF2 METTL3 IGF2BP2 HNRNPA2B1 FMR1 KIAA1429 METTL14 FTO WTAP YTHDF2 METTL14 YTHDF1 FMR1 HNRNPA2B1 METTL3 IGF2BP3 YTHDF2 METTL14 HNRNPA2B1 ALKBH5 YTHDF2 METTL14 FTO ALKBH5 YTHDF1 WTAP IGF2BP2 KIAA1429 METTL14 
## cv fold 7: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 WTAP KIAA1429 FMR1 HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 WTAP METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 WTAP KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 WTAP IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 WTAP KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 YTHDF2 WTAP KIAA1429 IGF2BP3 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 WTAP YTHDF2 FMR1 KIAA1429 IGF2BP3 WTAP HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 WTAP YTHDF2 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 WTAP YTHDF2 FMR1 YTHDF2 WTAP HNRNPA2B1 METTL3 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 FMR1 YTHDF2 WTAP HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 IGF2BP3 WTAP KIAA1429 METTL3 HNRNPA2B1 FMR1 YTHDF2 HNRNPC HNRNPA2B1 FMR1 KIAA1429 WTAP YTHDF2 METTL3 HNRNPA2B1 HNRNPC IGF2BP3 HNRNPA2B1 FMR1 YTHDF2 WTAP KIAA1429 FMR1 HNRNPA2B1 METTL3 YTHDF2 HNRNPC HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 IGF2BP3 KIAA1429 WTAP YTHDF2 FMR1 HNRNPA2B1 HNRNPC YTHDF2 FMR1 HNRNPA2B1 METTL3 WTAP HNRNPA2B1 HNRNPC YTHDF2 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 WTAP YTHDF2 METTL14 HNRNPA2B1 HNRNPC KIAA1429 FMR1 YTHDF2 METTL14 HNRNPA2B1 HNRNPC YTHDF2 FMR1 KIAA1429 WTAP HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 
## cv fold 8: FTO IGF2BP3 FTO IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 YTHDF1 METTL3 KIAA1429 IGF2BP3 METTL3 YTHDF1 IGF2BP3 KIAA1429 METTL3 YTHDF1 WTAP KIAA1429 WTAP YTHDF1 METTL3 IGF2BP3 KIAA1429 WTAP YTHDF1 METTL3 KIAA1429 WTAP YTHDF1 IGF2BP3 METTL3 KIAA1429 FMR1 YTHDF1 WTAP KIAA1429 FMR1 YTHDF1 WTAP IGF2BP3 KIAA1429 METTL3 YTHDF1 FMR1 KIAA1429 FMR1 YTHDF1 WTAP YTHDF1 METTL14 KIAA1429 IGF2BP3 METTL14 YTHDF1 FMR1 KIAA1429 METTL3 YTHDF1 METTL14 IGF2BP3 KIAA1429 METTL14 YTHDF1 WTAP KIAA1429 FMR1 YTHDF1 METTL14 IGF2BP3 KIAA1429 METTL14 YTHDF1 METTL3 KIAA1429 FMR1 YTHDF1 METTL14 IGF2BP3 KIAA1429 WTAP FTO METTL14 YTHDF1 METTL14 FTO FMR1 YTHDF1 METTL14 KIAA1429 IGF2BP3 HNRNPA2B1 METTL14 METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 METTL14 YTHDF1 FMR1 HNRNPA2B1 WTAP FTO METTL14 YTHDF1 METTL3 KIAA1429 FMR1 HNRNPA2B1 METTL14 IGF2BP3 YTHDF1 METTL14 FTO WTAP HNRNPA2B1 METTL3 IGF2BP2 KIAA1429 METTL14 HNRNPA2B1 FMR1 YTHDF1 FMR1 FTO METTL14 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 METTL14 KIAA1429 IGF2BP2 YTHDF1 FMR1 HNRNPA2B1 METTL3 METTL14 FTO WTAP HNRNPA2B1 METTL14 KIAA1429 IGF2BP3 YTHDF1 METTL14 METTL3 HNRNPA2B1 FMR1 FTO IGF2BP2 HNRNPA2B1 METTL14 KIAA1429 FMR1 YTHDF1 METTL3 HNRNPA2B1 METTL14 IGF2BP3 KIAA1429 METTL14 YTHDF1 WTAP FTO FMR1 HNRNPA2B1 METTL14 YTHDF1 METTL3 IGF2BP2 HNRNPA2B1 FMR1 KIAA1429 
## cv fold 9: FTO FTO FTO KIAA1429 KIAA1429 FTO METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP1 METTL3 KIAA1429 IGF2BP1 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP1 KIAA1429 METTL3 ZC3H13 IGF2BP3 METTL3 KIAA1429 IGF2BP1 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 ZC3H13 METTL3 KIAA1429 IGF2BP3 IGF2BP1 KIAA1429 METTL3 YTHDF2 METTL3 ZC3H13 IGF2BP3 METTL3 YTHDF2 KIAA1429 FMR1 ZC3H13 METTL3 YTHDF2 FMR1 YTHDF1 FMR1 KIAA1429 IGF2BP1 METTL3 YTHDF1 FMR1 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 YTHDF2 METTL3 HNRNPA2B1 FMR1 ZC3H13 METTL3 HNRNPA2B1 FMR1 YTHDF1 IGF2BP3 FMR1 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 IGF2BP1 METTL3 HNRNPA2B1 FMR1 YTHDF1 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 YTHDF2 HNRNPC HNRNPA2B1 FMR1 YTHDF1 FMR1 YTHDF2 HNRNPC HNRNPA2B1 METTL3 IGF2BP2 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 HNRNPC YTHDF2 FMR1 YTHDF1 IGF2BP1 FMR1 HNRNPA2B1 HNRNPC KIAA1429 METTL3 HNRNPA2B1 IGF2BP2 FMR1 YTHDF1 HNRNPC HNRNPA2B1 FMR1 YTHDF2 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP2 HNRNPC YTHDF1 FMR1 HNRNPA2B1 METTL3 YTHDF2 HNRNPC HNRNPA2B1 FMR1 YTHDF1 IGF2BP1 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP2 HNRNPC HNRNPA2B1 FMR1 YTHDF1 METTL3 HNRNPA2B1 HNRNPC YTHDF2 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 FMR1 YTHDF1 METTL3 IGF2BP2 HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 METTL3 YTHDF2 WTAP HNRNPA2B1 FMR1 IGF2BP1 YTHDF1 HNRNPC HNRNPA2B1 FMR1 YTHDF2 METTL3 HNRNPA2B1 HNRNPC IGF2BP2 KIAA1429 FMR1 YTHDF1 WTAP YTHDF2 ALKBH5 HNRNPA2B1 FMR1 KIAA1429 HNRNPC YTHDF1 METTL3 HNRNPA2B1 FMR1 IGF2BP2 HNRNPA2B1 ALKBH5 
## cv fold 10: KIAA1429 KIAA1429 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 FMR1 KIAA1429 METTL3 IGF2BP3 KIAA1429 FMR1 KIAA1429 FMR1 KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 KIAA1429 FMR1 KIAA1429 IGF2BP3 IGF2BP1 KIAA1429 FMR1 KIAA1429 METTL3 WTAP KIAA1429 FMR1 KIAA1429 IGF2BP1 HNRNPC KIAA1429 FMR1 KIAA1429 IGF2BP3 WTAP KIAA1429 FMR1 KIAA1429 IGF2BP1 METTL3 KIAA1429 HNRNPC KIAA1429 FMR1 WTAP KIAA1429 IGF2BP1 KIAA1429 FMR1 IGF2BP3 HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 METTL3 WTAP KIAA1429 IGF2BP1 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 HNRNPC KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 METTL3 IGF2BP1 HNRNPA2B1 FMR1 HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 HNRNPC YTHDF2 WTAP YTHDF2 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 HNRNPC FMR1 YTHDF2 WTAP KIAA1429 IGF2BP1 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 HNRNPC YTHDF2 FMR1 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 HNRNPC KIAA1429 FMR1 YTHDF2 WTAP IGF2BP3 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 WTAP YTHDF2 METTL3 IGF2BP1 YTHDF1 FMR1 HNRNPA2B1 HNRNPC KIAA1429 FMR1 YTHDF2 WTAP YTHDF1 FMR1 HNRNPA2B1 HNRNPC YTHDF2 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 YTHDF2 WTAP KIAA1429 HNRNPC YTHDF1 FMR1 YTHDF2 METTL3 HNRNPA2B1 FMR1 YTHDF1 HNRNPC HNRNPA2B1 FMR1 IGF2BP1 KIAA1429 WTAP YTHDF2 METTL3 HNRNPA2B1 FMR1 YTHDF1 HNRNPC YTHDF2 FMR1 HNRNPA2B1 HNRNPC KIAA1429 WTAP YTHDF2 FMR1 
## maximum partial log-likelihood at boosting step 20 
## iteration 2 : evaluating penalty 1944 
## cv fold 1: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 IGF2BP3 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 FTO KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP1 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP2 KIAA1429 METTL3 IGF2BP1 KIAA1429 METTL3 IGF2BP3 KIAA1429 IGF2BP2 KIAA1429 METTL3 IGF2BP1 KIAA1429 METTL3 FTO IGF2BP3 KIAA1429 METTL3 IGF2BP2 KIAA1429 METTL3 IGF2BP1 KIAA1429 METTL3 YTHDF1 IGF2BP2 KIAA1429 METTL3 IGF2BP1 YTHDF1 IGF2BP3 KIAA1429 METTL3 YTHDF1 IGF2BP2 METTL3 KIAA1429 IGF2BP1 YTHDF1 METTL3 IGF2BP2 KIAA1429 METTL3 YTHDF1 IGF2BP3 YTHDF1 IGF2BP1 METTL3 KIAA1429 IGF2BP2 YTHDF1 METTL3 HNRNPA2B1 WTAP IGF2BP3 KIAA1429 METTL3 HNRNPA2B1 IGF2BP1 METTL3 HNRNPA2B1 WTAP YTHDF1 IGF2BP2 METTL3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 IGF2BP1 YTHDF1 METTL3 HNRNPA2B1 WTAP IGF2BP2 KIAA1429 METTL3 HNRNPA2B1 WTAP YTHDF1 METTL3 IGF2BP2 HNRNPA2B1 METTL3 KIAA1429 IGF2BP1 WTAP HNRNPA2B1 FMR1 YTHDF1 IGF2BP3 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 IGF2BP2 KIAA1429 METTL3 YTHDF1 FMR1 HNRNPA2B1 WTAP IGF2BP1 KIAA1429 FMR1 YTHDF1 METTL3 HNRNPA2B1 FMR1 ZC3H13 IGF2BP2 WTAP HNRNPA2B1 METTL3 YTHDF1 FMR1 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP1 YTHDF1 WTAP HNRNPA2B1 FMR1 IGF2BP2 KIAA1429 METTL3 HNRNPA2B1 FMR1 YTHDF1 WTAP ZC3H13 FMR1 HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 FMR1 YTHDF1 IGF2BP1 METTL3 KIAA1429 FMR1 HNRNPA2B1 WTAP YTHDF1 IGF2BP2 
## cv fold 2: KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 METTL3 KIAA1429 METTL3 KIAA1429 FMR1 FTO FMR1 KIAA1429 METTL3 KIAA1429 FMR1 FTO FMR1 KIAA1429 METTL3 KIAA1429 FMR1 KIAA1429 FMR1 FTO METTL3 KIAA1429 FMR1 KIAA1429 FMR1 IGF2BP1 KIAA1429 METTL3 KIAA1429 FMR1 FTO FMR1 KIAA1429 IGF2BP1 METTL3 KIAA1429 FMR1 KIAA1429 FMR1 ZC3H13 IGF2BP1 METTL3 KIAA1429 FMR1 KIAA1429 FMR1 ZC3H13 METTL3 KIAA1429 IGF2BP1 FMR1 ZC3H13 KIAA1429 FMR1 METTL3 ZC3H13 FMR1 KIAA1429 IGF2BP1 KIAA1429 FMR1 ZC3H13 METTL3 KIAA1429 FMR1 ZC3H13 FMR1 KIAA1429 IGF2BP1 METTL3 KIAA1429 FMR1 ZC3H13 FMR1 KIAA1429 IGF2BP1 METTL3 ZC3H13 FMR1 KIAA1429 FMR1 ZC3H13 FMR1 KIAA1429 IGF2BP1 KIAA1429 METTL3 YTHDC2 FMR1 ZC3H13 FMR1 KIAA1429 WTAP YTHDC2 METTL3 FMR1 KIAA1429 IGF2BP1 WTAP YTHDC2 FMR1 KIAA1429 METTL3 ZC3H13 WTAP YTHDC2 FMR1 KIAA1429 WTAP HNRNPA2B1 FMR1 IGF2BP1 KIAA1429 METTL3 HNRNPA2B1 FMR1 YTHDC2 WTAP KIAA1429 METTL3 HNRNPA2B1 FMR1 IGF2BP1 HNRNPA2B1 FMR1 ZC3H13 METTL3 HNRNPA2B1 FMR1 KIAA1429 WTAP YTHDC2 METTL3 WTAP HNRNPA2B1 FMR1 KIAA1429 IGF2BP1 HNRNPA2B1 FMR1 METTL3 HNRNPA2B1 FMR1 FTO WTAP YTHDC2 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 IGF2BP1 WTAP KIAA1429 FMR1 HNRNPA2B1 METTL3 KIAA1429 FMR1 IGF2BP2 HNRNPA2B1 METTL3 YTHDC2 WTAP HNRNPA2B1 FMR1 IGF2BP2 KIAA1429 METTL3 HNRNPA2B1 FMR1 IGF2BP1 HNRNPA2B1 WTAP FTO FMR1 HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 FMR1 KIAA1429 WTAP YTHDC2 METTL3 HNRNPA2B1 FMR1 IGF2BP2 HNRNPA2B1 METTL3 
## cv fold 3: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 FTO IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP1 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP1 KIAA1429 FMR1 KIAA1429 FMR1 KIAA1429 METTL3 IGF2BP3 KIAA1429 FMR1 KIAA1429 IGF2BP1 METTL3 KIAA1429 FMR1 KIAA1429 FMR1 FTO IGF2BP1 KIAA1429 FMR1 KIAA1429 METTL3 IGF2BP3 KIAA1429 FMR1 KIAA1429 FMR1 KIAA1429 METTL3 FTO FMR1 KIAA1429 IGF2BP1 FMR1 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 FMR1 KIAA1429 FMR1 IGF2BP1 KIAA1429 FMR1 FTO METTL3 KIAA1429 FMR1 KIAA1429 ALKBH5 FTO ALKBH5 KIAA1429 IGF2BP1 FMR1 KIAA1429 ALKBH5 FTO ALKBH5 KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 KIAA1429 ALKBH5 FTO ALKBH5 KIAA1429 IGF2BP1 FMR1 KIAA1429 ALKBH5 FTO ALKBH5 KIAA1429 IGF2BP3 KIAA1429 FMR1 ALKBH5 KIAA1429 FTO ALKBH5 IGF2BP1 KIAA1429 FMR1 KIAA1429 ALKBH5 FTO ALKBH5 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 IGF2BP1 ALKBH5 FTO METTL3 HNRNPA2B1 ALKBH5 KIAA1429 IGF2BP3 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 ALKBH5 KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 ALKBH5 FTO FMR1 HNRNPA2B1 IGF2BP1 KIAA1429 ALKBH5 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 ALKBH5 FTO FMR1 HNRNPA2B1 ALKBH5 IGF2BP3 
## cv fold 4: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP1 KIAA1429 FMR1 FTO FMR1 KIAA1429 METTL3 IGF2BP1 KIAA1429 FMR1 IGF2BP3 KIAA1429 FMR1 KIAA1429 METTL3 IGF2BP1 KIAA1429 FMR1 KIAA1429 IGF2BP3 FMR1 KIAA1429 METTL3 FTO FMR1 KIAA1429 IGF2BP1 FMR1 KIAA1429 METTL3 KIAA1429 IGF2BP3 FMR1 KIAA1429 IGF2BP1 ZC3H13 FMR1 KIAA1429 FMR1 ZC3H13 METTL3 KIAA1429 FMR1 IGF2BP1 KIAA1429 FMR1 ZC3H13 METTL3 ZC3H13 FMR1 KIAA1429 IGF2BP3 FMR1 KIAA1429 METTL3 ZC3H13 FMR1 KIAA1429 IGF2BP1 FMR1 KIAA1429 METTL3 ZC3H13 FMR1 ZC3H13 IGF2BP1 FMR1 KIAA1429 YTHDF2 FMR1 METTL3 YTHDF2 IGF2BP3 KIAA1429 FMR1 ZC3H13 FMR1 YTHDF2 METTL3 KIAA1429 FMR1 ZC3H13 FMR1 YTHDF2 IGF2BP1 METTL3 KIAA1429 FMR1 YTHDF2 FMR1 ZC3H13 METTL3 YTHDF2 FMR1 KIAA1429 IGF2BP3 ZC3H13 FMR1 YTHDF2 FMR1 KIAA1429 METTL3 IGF2BP1 KIAA1429 FMR1 ZC3H13 FMR1 YTHDF2 METTL3 YTHDF2 FMR1 ZC3H13 FMR1 YTHDF2 METTL3 HNRNPA2B1 
## cv fold 5: FTO FTO FTO FTO IGF2BP3 FTO IGF2BP3 FTO IGF2BP3 FTO IGF2BP3 FTO IGF2BP3 FTO IGF2BP3 IGF2BP3 FTO IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 FTO KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP2 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP2 KIAA1429 METTL3 KIAA1429 IGF2BP3 IGF2BP2 KIAA1429 METTL3 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP2 FMR1 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 HNRNPA2B1 FMR1 FTO FMR1 HNRNPA2B1 IGF2BP2 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 IGF2BP1 FMR1 HNRNPA2B1 IGF2BP2 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 IGF2BP2 HNRNPA2B1 METTL3 IGF2BP1 HNRNPA2B1 FMR1 KIAA1429 WTAP FTO FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP2 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP1 FMR1 KIAA1429 WTAP HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP2 HNRNPA2B1 FMR1 FTO WTAP HNRNPA2B1 METTL3 IGF2BP1 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 IGF2BP2 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 WTAP HNRNPA2B1 IGF2BP2 METTL3 HNRNPA2B1 FMR1 FTO IGF2BP1 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 FMR1 IGF2BP2 HNRNPA2B1 WTAP FTO FMR1 HNRNPA2B1 METTL3 IGF2BP1 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 FMR1 KIAA1429 WTAP HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP1 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP2 FMR1 HNRNPA2B1 METTL3 KIAA1429 WTAP FTO FMR1 HNRNPA2B1 
## cv fold 6: KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 WTAP METTL3 KIAA1429 IGF2BP3 KIAA1429 WTAP METTL3 FTO WTAP HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 FMR1 KIAA1429 WTAP HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 FTO WTAP KIAA1429 IGF2BP3 HNRNPA2B1 FMR1 METTL3 HNRNPA2B1 FMR1 YTHDF2 WTAP HNRNPA2B1 METTL3 YTHDF2 FMR1 KIAA1429 IGF2BP3 WTAP HNRNPA2B1 FMR1 YTHDF2 METTL3 HNRNPA2B1 WTAP YTHDF2 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 YTHDF2 WTAP KIAA1429 FMR1 YTHDF2 METTL3 HNRNPA2B1 WTAP IGF2BP3 HNRNPA2B1 FMR1 YTHDF2 METTL3 HNRNPA2B1 FMR1 FTO WTAP YTHDF2 FMR1 HNRNPA2B1 METTL3 YTHDF2 WTAP FMR1 HNRNPA2B1 IGF2BP3 YTHDF2 METTL3 HNRNPA2B1 FMR1 WTAP YTHDF2 IGF2BP2 HNRNPA2B1 FMR1 KIAA1429 HNRNPC HNRNPA2B1 METTL3 WTAP YTHDF2 FMR1 HNRNPA2B1 METTL3 YTHDF1 FMR1 YTHDF2 WTAP FTO IGF2BP2 HNRNPA2B1 FMR1 HNRNPC HNRNPA2B1 METTL3 YTHDF2 FMR1 YTHDF1 WTAP YTHDF2 FMR1 HNRNPA2B1 HNRNPC KIAA1429 IGF2BP2 FMR1 HNRNPA2B1 METTL3 YTHDF1 IGF2BP3 HNRNPA2B1 FMR1 HNRNPC YTHDF2 WTAP KIAA1429 FMR1 HNRNPA2B1 METTL3 YTHDF1 IGF2BP2 HNRNPC 
## cv fold 7: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 WTAP KIAA1429 WTAP IGF2BP3 KIAA1429 WTAP FTO WTAP KIAA1429 IGF2BP3 WTAP KIAA1429 FMR1 KIAA1429 WTAP FTO FMR1 KIAA1429 WTAP KIAA1429 IGF2BP3 FMR1 KIAA1429 WTAP FTO FMR1 KIAA1429 WTAP KIAA1429 FMR1 IGF2BP3 KIAA1429 WTAP FTO FMR1 HNRNPA2B1 WTAP KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 FMR1 FTO WTAP HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 FMR1 KIAA1429 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 FTO IGF2BP3 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 WTAP KIAA1429 HNRNPC HNRNPA2B1 FMR1 KIAA1429 METTL3 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 HNRNPC KIAA1429 METTL3 HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 WTAP IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 HNRNPC FTO FMR1 HNRNPA2B1 METTL3 WTAP KIAA1429 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 HNRNPC KIAA1429 FMR1 METTL3 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 WTAP KIAA1429 FMR1 HNRNPA2B1 HNRNPC HNRNPA2B1 FMR1 FTO METTL3 HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 WTAP KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 HNRNPC IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 HNRNPC KIAA1429 METTL3 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 HNRNPC KIAA1429 WTAP METTL3 HNRNPA2B1 FMR1 FTO IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 
## cv fold 8: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 FMR1 YTHDF2 METTL3 KIAA1429 FMR1 YTHDF2 FMR1 YTHDF2 METTL3 IGF2BP3 KIAA1429 FMR1 YTHDF2 FMR1 KIAA1429 METTL3 YTHDF2 FMR1 YTHDF2 IGF2BP3 KIAA1429 FMR1 METTL3 YTHDF2 FMR1 KIAA1429 IGF2BP3 YTHDF2 FMR1 KIAA1429 METTL3 YTHDF2 FMR1 YTHDF2 FMR1 KIAA1429 METTL3 YTHDF2 FMR1 IGF2BP3 KIAA1429 METTL3 YTHDF2 FMR1 YTHDF2 HNRNPC KIAA1429 FMR1 YTHDF2 HNRNPC KIAA1429 FMR1 YTHDF2 METTL3 YTHDF2 FMR1 HNRNPC KIAA1429 IGF2BP3 HNRNPA2B1 FMR1 YTHDF2 METTL3 HNRNPA2B1 HNRNPC YTHDF2 FMR1 KIAA1429 FMR1 HNRNPA2B1 HNRNPC YTHDF2 METTL3 HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 HNRNPC YTHDF2 FMR1 KIAA1429 HNRNPC HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 HNRNPC IGF2BP3 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 HNRNPC YTHDF2 FMR1 HNRNPA2B1 METTL3 IGF2BP3 YTHDF2 FMR1 HNRNPA2B1 HNRNPC YTHDF2 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 HNRNPC YTHDF2 FMR1 KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 HNRNPC YTHDF2 FMR1 HNRNPA2B1 METTL3 YTHDF2 FMR1 
## cv fold 9: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 WTAP KIAA1429 METTL3 IGF2BP3 KIAA1429 WTAP KIAA1429 METTL3 IGF2BP3 KIAA1429 WTAP KIAA1429 WTAP METTL3 KIAA1429 IGF2BP3 HNRNPA2B1 WTAP METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 WTAP HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 WTAP IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 FMR1 KIAA1429 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 WTAP HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 WTAP KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 KIAA1429 FMR1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 WTAP METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 WTAP KIAA1429 FMR1 HNRNPA2B1 HNRNPC METTL3 HNRNPA2B1 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 HNRNPC IGF2BP3 HNRNPA2B1 FMR1 YTHDF1 METTL3 HNRNPA2B1 WTAP KIAA1429 FMR1 YTHDF1 HNRNPC HNRNPA2B1 FMR1 IGF2BP3 KIAA1429 METTL3 HNRNPA2B1 HNRNPC YTHDF1 FMR1 HNRNPA2B1 WTAP IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 FMR1 YTHDF1 HNRNPC HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 IGF2BP3 YTHDF1 WTAP KIAA1429 
## cv fold 10: KIAA1429 KIAA1429 ZC3H13 KIAA1429 ZC3H13 KIAA1429 ZC3H13 KIAA1429 ZC3H13 KIAA1429 ZC3H13 KIAA1429 ZC3H13 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 ZC3H13 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 WTAP ZC3H13 METTL3 HNRNPA2B1 WTAP METTL3 KIAA1429 IGF2BP3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 METTL3 KIAA1429 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 WTAP KIAA1429 METTL3 HNRNPA2B1 WTAP KIAA1429 IGF2BP3 METTL3 HNRNPA2B1 WTAP HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 WTAP HNRNPA2B1 IGF2BP3 KIAA1429 METTL3 HNRNPA2B1 WTAP METTL3 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 WTAP KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 WTAP KIAA1429 METTL3 IGF2BP3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 WTAP IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 METTL3 KIAA1429 WTAP IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 WTAP KIAA1429 IGF2BP3 METTL3 HNRNPA2B1 WTAP HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 WTAP KIAA1429 METTL3 HNRNPA2B1 WTAP HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 WTAP HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 WTAP HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 WTAP METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 WTAP METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 WTAP IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 WTAP HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 WTAP KIAA1429 
## maximum partial log-likelihood at boosting step 29 
## iteration 3 : evaluating penalty 3888 
## cv fold 1: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 KIAA1429 METTL3 HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 
## cv fold 2: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 HNRNPC KIAA1429 HNRNPC KIAA1429 IGF2BP3 METTL3 KIAA1429 WTAP KIAA1429 HNRNPC KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 KIAA1429 HNRNPC WTAP KIAA1429 WTAP KIAA1429 METTL3 IGF2BP3 KIAA1429 HNRNPC KIAA1429 WTAP KIAA1429 HNRNPC KIAA1429 METTL3 IGF2BP3 KIAA1429 WTAP KIAA1429 HNRNPC WTAP KIAA1429 METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 HNRNPC HNRNPA2B1 METTL3 KIAA1429 HNRNPC HNRNPA2B1 WTAP IGF2BP3 KIAA1429 METTL3 HNRNPA2B1 HNRNPC HNRNPA2B1 FMR1 KIAA1429 IGF2BP1 METTL3 HNRNPA2B1 WTAP HNRNPA2B1 FMR1 FTO METTL3 HNRNPA2B1 IGF2BP3 FMR1 HNRNPA2B1 HNRNPC KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP1 KIAA1429 WTAP HNRNPA2B1 FMR1 HNRNPA2B1 HNRNPC KIAA1429 METTL3 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 HNRNPC IGF2BP1 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 WTAP KIAA1429 HNRNPC HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 IGF2BP1 KIAA1429 FMR1 HNRNPA2B1 
## cv fold 3: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 KIAA1429 IGF2BP3 FTO IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 FMR1 KIAA1429 FMR1 KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 KIAA1429 FMR1 KIAA1429 IGF2BP3 KIAA1429 FMR1 METTL3 KIAA1429 IGF2BP3 KIAA1429 FMR1 FTO FMR1 KIAA1429 METTL3 KIAA1429 FMR1 IGF2BP3 KIAA1429 FMR1 KIAA1429 METTL3 FTO FMR1 KIAA1429 IGF2BP3 FMR1 KIAA1429 METTL3 KIAA1429 FMR1 KIAA1429 IGF2BP3 KIAA1429 FMR1 FTO FMR1 KIAA1429 METTL3 IGF2BP3 KIAA1429 FMR1 KIAA1429 FMR1 FTO METTL3 KIAA1429 FMR1 IGF2BP3 KIAA1429 FMR1 KIAA1429 IGF2BP3 KIAA1429 METTL3 FMR1 KIAA1429 FMR1 FTO KIAA1429 FMR1 IGF2BP3 KIAA1429 METTL3 KIAA1429 FMR1 IGF2BP2 KIAA1429 FMR1 FTO METTL3 KIAA1429 FMR1 IGF2BP2 
## cv fold 4: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO METTL3 KIAA1429 METTL3 KIAA1429 METTL3 KIAA1429 METTL3 FTO METTL3 KIAA1429 METTL3 KIAA1429 METTL3 KIAA1429 FTO METTL3 IGF2BP1 KIAA1429 WTAP KIAA1429 WTAP METTL3 KIAA1429 IGF2BP1 WTAP KIAA1429 METTL3 KIAA1429 WTAP FTO WTAP IGF2BP1 KIAA1429 METTL3 WTAP KIAA1429 IGF2BP1 KIAA1429 WTAP METTL3 FTO WTAP KIAA1429 WTAP KIAA1429 METTL3 IGF2BP1 KIAA1429 WTAP FTO WTAP METTL3 KIAA1429 IGF2BP1 KIAA1429 WTAP METTL3 KIAA1429 WTAP FTO IGF2BP1 WTAP KIAA1429 METTL3 KIAA1429 WTAP IGF2BP1 KIAA1429 METTL3 WTAP KIAA1429 IGF2BP3 KIAA1429 WTAP METTL3 KIAA1429 IGF2BP1 WTAP FTO WTAP KIAA1429 IGF2BP3 METTL3 KIAA1429 WTAP KIAA1429 IGF2BP1 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 WTAP FTO METTL3 KIAA1429 WTAP IGF2BP1 HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 WTAP KIAA1429 IGF2BP1 METTL3 HNRNPA2B1 WTAP KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 WTAP HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 HNRNPA2B1 WTAP METTL3 HNRNPA2B1 IGF2BP1 KIAA1429 WTAP METTL3 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 IGF2BP3 KIAA1429 WTAP HNRNPA2B1 METTL3 HNRNPA2B1 WTAP IGF2BP1 KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 WTAP KIAA1429 IGF2BP3 METTL3 HNRNPA2B1 WTAP HNRNPA2B1 METTL3 KIAA1429 IGF2BP3 IGF2BP1 
## cv fold 5: IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 WTAP KIAA1429 METTL3 IGF2BP3 KIAA1429 WTAP KIAA1429 METTL3 WTAP KIAA1429 IGF2BP3 KIAA1429 METTL3 WTAP KIAA1429 WTAP KIAA1429 METTL3 IGF2BP3 KIAA1429 WTAP KIAA1429 METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 WTAP KIAA1429 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 WTAP KIAA1429 METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 WTAP KIAA1429 METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 KIAA1429 WTAP KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 KIAA1429 WTAP METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 WTAP KIAA1429 METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 KIAA1429 WTAP KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 METTL3 KIAA1429 WTAP METTL3 KIAA1429 
## cv fold 6: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 FTO METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP2 FMR1 KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 KIAA1429 IGF2BP2 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 IGF2BP3 KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP2 HNRNPA2B1 FMR1 FTO METTL3 HNRNPA2B1 FMR1 HNRNPA2B1 IGF2BP2 METTL3 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 IGF2BP2 KIAA1429 FMR1 HNRNPA2B1 METTL3 FMR1 HNRNPA2B1 IGF2BP2 KIAA1429 FMR1 HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 FMR1 FTO METTL3 HNRNPA2B1 FMR1 YTHDF2 IGF2BP2 HNRNPA2B1 FMR1 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 IGF2BP2 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 FMR1 KIAA1429 METTL3 IGF2BP2 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 YTHDF2 IGF2BP3 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP2 HNRNPA2B1 FMR1 YTHDF2 METTL3 IGF2BP3 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 IGF2BP2 FMR1 HNRNPA2B1 METTL3 YTHDF2 FMR1 HNRNPA2B1 IGF2BP3 
## cv fold 7: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 METTL3 KIAA1429 METTL3 KIAA1429 METTL3 FTO KIAA1429 METTL3 KIAA1429 METTL3 FTO METTL3 KIAA1429 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 FTO IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 FTO IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 WTAP KIAA1429 METTL3 KIAA1429 IGF2BP1 WTAP KIAA1429 IGF2BP3 METTL3 KIAA1429 WTAP FTO FMR1 ZC3H13 FMR1 KIAA1429 WTAP ZC3H13 FMR1 KIAA1429 IGF2BP1 METTL3 KIAA1429 WTAP ZC3H13 FMR1 KIAA1429 IGF2BP3 WTAP KIAA1429 FMR1 FTO METTL3 ZC3H13 FMR1 KIAA1429 IGF2BP1 WTAP KIAA1429 FMR1 ZC3H13 WTAP KIAA1429 FMR1 ZC3H13 METTL3 IGF2BP1 KIAA1429 FMR1 HNRNPA2B1 WTAP FTO METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 WTAP HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 IGF2BP1 FMR1 HNRNPA2B1 METTL3 KIAA1429 WTAP HNRNPA2B1 FMR1 FTO IGF2BP3 HNRNPA2B1 FMR1 METTL3 HNRNPA2B1 WTAP KIAA1429 FMR1 HNRNPA2B1 IGF2BP1 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 WTAP HNRNPA2B1 FMR1 FTO METTL3 HNRNPA2B1 IGF2BP3 FMR1 YTHDF1 KIAA1429 WTAP IGF2BP1 
## cv fold 8: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 IGF2BP1 KIAA1429 IGF2BP1 KIAA1429 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 IGF2BP3 KIAA1429 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 KIAA1429 IGF2BP3 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 IGF2BP3 KIAA1429 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 IGF2BP1 KIAA1429 IGF2BP3 KIAA1429 IGF2BP1 KIAA1429 IGF2BP3 IGF2BP3 KIAA1429 IGF2BP1 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP1 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 IGF2BP1 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP1 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP1 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 IGF2BP1 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP1 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP1 IGF2BP3 KIAA1429 METTL3 KIAA1429 FMR1 IGF2BP1 KIAA1429 METTL3 IGF2BP3 KIAA1429 FMR1 KIAA1429 METTL3 KIAA1429 FMR1 IGF2BP1 KIAA1429 WTAP IGF2BP3 KIAA1429 FMR1 KIAA1429 WTAP IGF2BP1 KIAA1429 FMR1 KIAA1429 METTL3 IGF2BP3 KIAA1429 WTAP FMR1 KIAA1429 IGF2BP1 KIAA1429 FMR1 WTAP KIAA1429 IGF2BP3 KIAA1429 METTL3 FMR1 KIAA1429 IGF2BP1 WTAP KIAA1429 FMR1 KIAA1429 WTAP KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 IGF2BP1 KIAA1429 WTAP KIAA1429 FMR1 IGF2BP1 KIAA1429 
## cv fold 9: KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 FMR1 KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 KIAA1429 IGF2BP3 METTL3 KIAA1429 FMR1 KIAA1429 FMR1 KIAA1429 IGF2BP3 ZC3H13 FMR1 KIAA1429 METTL3 FMR1 ZC3H13 KIAA1429 FMR1 IGF2BP3 KIAA1429 METTL3 ZC3H13 FMR1 KIAA1429 FMR1 ZC3H13 METTL3 KIAA1429 IGF2BP3 FMR1 ZC3H13 KIAA1429 FMR1 METTL3 ZC3H13 FMR1 KIAA1429 IGF2BP3 KIAA1429 FMR1 ZC3H13 METTL3 KIAA1429 FMR1 ZC3H13 FMR1 KIAA1429 METTL3 ZC3H13 FMR1 IGF2BP3 KIAA1429 FMR1 ZC3H13 METTL3 KIAA1429 FMR1 ZC3H13 FMR1 KIAA1429 IGF2BP3 KIAA1429 METTL3 ZC3H13 FMR1 KIAA1429 FMR1 ZC3H13 FMR1 KIAA1429 METTL3 IGF2BP3 ZC3H13 FMR1 KIAA1429 METTL3 ZC3H13 FMR1 KIAA1429 FMR1 ZC3H13 IGF2BP3 KIAA1429 FMR1 METTL3 KIAA1429 FMR1 ZC3H13 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 FMR1 HNRNPA2B1 FMR1 HNRNPA2B1 METTL3 ZC3H13 FMR1 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 KIAA1429 FMR1 HNRNPA2B1 METTL3 HNRNPA2B1 IGF2BP3 METTL3 HNRNPA2B1 FMR1 KIAA1429 IGF2BP3 HNRNPA2B1 FMR1 KIAA1429 METTL3 HNRNPA2B1 FMR1 ZC3H13 FMR1 HNRNPA2B1 METTL3 
## cv fold 10: FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 FTO KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 FTO METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 IGF2BP3 METTL3 KIAA1429 IGF2BP3 KIAA1429 METTL3 KIAA1429 METTL3 IGF2BP3 KIAA1429 METTL3 KIAA1429 WTAP IGF2BP3 KIAA1429 WTAP FTO METTL3 HNRNPA2B1 WTAP KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 WTAP KIAA1429 IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 METTL3 KIAA1429 WTAP IGF2BP3 HNRNPA2B1 METTL3 HNRNPA2B1 WTAP KIAA1429 IGF2BP3 METTL3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 HNRNPA2B1 METTL3 KIAA1429 WTAP HNRNPA2B1 METTL3 IGF2BP3 HNRNPA2B1 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 WTAP KIAA1429 METTL3 HNRNPA2B1 IGF2BP3 
## maximum partial log-likelihood at boosting step 124


pen$penalty
## [1] 3888

4. 再次构建优化后的模型

因为数据的问题，选择的基因数量过少，因此使用优化过的参数将筛选不出来变量，暂且不适用penalty参数，只是设为100。

## # Fit with optimal number of boosting steps
cbfitOpt <- CoxBoost(time = trainData$time, status = trainData$status, x = train.x,
    stepno = cv.res$optimal.step, penalty = 100)

可以在summary中复制筛选后的基因，也可以使用以下方式获取

summary(cbfitOpt)
## 3 boosting steps resulting in 2 non-zero coefficients  
## partial log-likelihood: -492.9381 
## 
## parameter estimates > 0:
##  KIAA1429 
## parameter estimates < 0:
##  IGF2BP3

5. 验证集验证

test.x <- as.matrix(testData[, 6:24])
step.logplik <- predict(cbfitOpt, newdata = test.x, newtime = testData$time, newstatus = testData$status,
    type = "logplik")

6. 预测预后风险

RiskScore <- predict(cbfitOpt, newdata = test.x, newtime = testData$time, newstatus = testData$status,
    type = "lp")
RiskScore = t(RiskScore)[, 1]
test.x$RiskScore = RiskScore

7. 一致性 C-index分析

summary(coxph(Surv(testData$time, testData$status) ~ RiskScore, test.x))$concordance[1]
##         C 
## 0.5146199

8. 生存分析

library(survival)
library(survminer)
groups <- ifelse(RiskScore>median(RiskScore),"high","low")
f <- survfit(Surv(testData$time, testData$status) ~ groups)
f
## Call: survfit(formula = Surv(testData$time, testData$status) ~ groups)
## 
##              n events median 0.95LCL 0.95UCL
## groups=high 73     21   1656     916      NA
## groups=low  74     25   1058     539      NA

ggsurvplot(f,
           data = testData,
           surv.median.line = "hv", 
           #legend.title = "Risk Group",
           #legend.labs = c("Low Risk", "High Risk"),
           pval = TRUE, 
           ggtheme = theme_bw()
)

0b0eb15423809ed94088c6a83934c577.png

9. 准确性分析ROC

library(InformationValue)
actuals <- testData$status
misClassError(actuals, RiskScore)
## [1] 0.3197
plotROC(actuals, RiskScore)

d3be347e530d7bbb08d05c95a34d67d1.png

Reference

  1. Binder, H., Benner, A., Bullinger, L., and Schumacher, M. (2013). Tailoring sparse multivariable regression techniques for prognostic single-nucleotide polymorphism signatures. Statistics in Medicine, doi: 10.1002/sim.5490.

  2. Binder, H., Allignol, A., Schumacher, M., and Beyersmann, J. (2009). Boosting for high-dimensional time-to-event data with competing risks. Bioinformatics, 25:890-896.

  3. Binder, H. and Schumacher, M. (2009). Incorporating pathway information into boosting estimation of high-dimensional risk prediction models. BMC Bioinformatics. 10:18.

  4. Binder, H. and Schumacher, M. (2008). Allowing for mandatory covariates in boosting estimation of sparse high-dimensional survival models. BMC Bioinformatics. 9:14.

  5. Tutz, G. and Binder, H. (2007) Boosting ridge regression. Computational Statistics Data Analysis, 51(12):6044-6059.

  6. Fine, J. P. and Gray, R. J. (1999). A proportional hazards model for the subdistribution of a competing risk. Journal of the American Statistical Association. 94:496-509.

基于机器学习构建临床预测模型

MachineLearning 1. 主成分分析（PCA）

MachineLearning 2. 因子分析（Factor Analysis）

MachineLearning 3. 聚类分析（Cluster Analysis）

MachineLearning 4. 癌症诊断方法之 K-邻近算法（KNN）

MachineLearning 5. 癌症诊断和分子分型方法之支持向量机（SVM)

MachineLearning 6. 癌症诊断机器学习之分类树（Classification Trees)

MachineLearning 7. 癌症诊断机器学习之回归树（Regression Trees)

MachineLearning 8. 癌症诊断机器学习之随机森林（Random Forest)

MachineLearning 9. 癌症诊断机器学习之梯度提升算法（Gradient Boosting)

MachineLearning 10. 癌症诊断机器学习之神经网络（Neural network)

MachineLearning 11. 机器学习之随机森林生存分析（randomForestSRC）

MachineLearning 12. 机器学习之降维方法t-SNE及可视化(Rtsne)

MachineLearning 13. 机器学习之降维方法UMAP及可视化 (umap)

MachineLearning 14. 机器学习之集成分类器(AdaBoost)

MachineLearning 15. 机器学习之集成分类器(LogitBoost)

MachineLearning 16. 机器学习之梯度提升机(GBM)

MachineLearning 17. 机器学习之围绕中心点划分算法(PAM)

MachineLearning 18. 机器学习之贝叶斯分析类器(Naive Bayes)

MachineLearning 19. 机器学习之神经网络分类器(NNET)

MachineLearning 20. 机器学习之袋装分类回归树(Bagged CART)

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好的，我明白了，我会按照你的要求回答问题。以下是我的回答： 1. 逻辑回归模型是一种广泛应用于分类问题的统计学习模型。它是建立在线性回归模型的基础之上，通过对线性模型的输出进行逻辑变换，将连续的输出转化为概率的形式，从而实现对分类问题的建模。逻辑回归模型的核心思想是通过对样本的特征进行加权求和，得到样本的线性得分，然后将线性得分转化为概率的形式，最终进行分类决策。 2. 逻辑回归模型的参数估计算法通常采用最大似然估计法。最大似然估计法的核心思想是寻找一组最优的模型参数，使得在给定模型的情况下，观测数据出现的可能性最大化。在逻辑回归模型中，最大似然估计法的目标是使得模型的预测概率与观测数据的标签一致的概率最大化。具体来说，可以通过梯度下降算法等优化方法来求解最大似然估计问题。 下面是使用Python代码实现逻辑回归模型的参数估计过程的示例： ```python import numpy as np from scipy.optimize import minimize def sigmoid(x): return 1 / (1 + np.exp(-x)) def log_likelihood(theta, X, y): z = np.dot(X, theta) log_like = np.sum(y * z - np.log(1 + np.exp(z))) return log_like def logistic_regression(X, y): n, p = X.shape X = np.hstack((np.ones((n, 1)), X)) theta_init = np.zeros(p + 1) res = minimize(lambda theta: -log_likelihood(theta, X, y), theta_init, method='BFGS') return res.x # 测试代码 X = np.array([[1, 2], [3, 4], [5, 6]]) y = np.array([0, 1, 0]) theta = logistic_regression(X, y) print(theta) ``` 以上代码中，sigmoid函数用来对线性得分进行逻辑变换，log_likelihood函数用来计算给定模型参数下的最大似然估计值，logistic_regression函数用来对数据进行预处理，并通过最大化似然估计值来求解逻辑回归模型的参数。

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